Pitfalls and Challenges in Nanotoxicology: A Case of Cobalt Ferrite (CoFe2O4) Nanocomposites

被引：47
作者：
Ahmad, Farooq [1 ,2 ]
Zhou, Ying [1 ,3 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Zhejiang, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Met Matrix Composites, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
[3] Zhejiang Univ Technol, Res Ctr Anal & Measurement, 18 Chaowang Rd, Hangzhou 310032, Zhejiang, Peoples R China
来源：
CHEMICAL RESEARCH IN TOXICOLOGY | 2017年 / 30卷 / 02期
关键词：
IRON-OXIDE NANOPARTICLES; BOVINE SERUM-ALBUMIN; IN-VIVO; OXIDATIVE STRESS; MAGNETIC NANOPARTICLES; ZINC-OXIDE; INDUCED CYTOTOXICITY; CORONA FORMATION; PARTICLE-SIZE; HUMAN SKIN;
D O I：
10.1021/acs.chemrestox.6b00377
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nanotechnology is developing at a rapid pace with promises of a brilliant socio-economic future. The apprehensions of vivid future involvement with nano technology make nanoobjects ubiquitous in the macroscopic world of humans. Nanotechnology helps us to visualize the new mysterious horizons in engineering, sophisticated electronics, environmental remediation, biosensing, and nanomedicine. In all these hotspots, cobalt ferrite (CoFe) nanoparticles (NPs) are outstanding contestants because of their astonishing controllable physicochemical and magnetic properties with ease of synthesis methods. The extensive use of CoFe NPs may result in CoFe NPs easily penetrating the human body unintentionally by ingestion, inhalation, adsorption, etc. and intentionally being instilled into the human body during biomedical diagnostics and treatment. After being housed in the human body, it might induce oxidative stress, cytotoxicity, genotoxicity, inflammation, apoptosis, and developmental, metabolic and hormonal abnormalities. In this review, we compiled the toxicity knowledge of CoFe NPs aimed to provide the safe usage of this breed of nanomaterials.
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收藏
页码：492 / 507
页数：16
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