Prognostic value of saturated prostate cryoablation for localized prostate cancer

被引:6
作者
Chen, Chung-Hsin [1 ]
Tai, Yi-Sheng [2 ]
Pu, Yeong-Shiau [1 ]
机构
[1] Natl Taiwan Univ, Coll Med & Hosp, Dept Urol, Taipei 10764, Taiwan
[2] Natl Taiwan Univ Hosp, Yun Lin Branch, Dept Urol, Yunlin, Taiwan
关键词
Cryotherapy; Cryosurgery; Prostate tumor; Prostate volume; Complication; ANDROGEN DEPRIVATION THERAPY; SALVAGE CRYOABLATION; BIOCHEMICAL FAILURE; GLAND; RADIOTHERAPY; CRYOSURGERY; PREDICTORS; REGISTRY; MEN;
D O I
10.1007/s00345-014-1467-2
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
To evaluate the oncological outcomes and complications of patients with saturated prostate cryoablation. A cohort of 208 patients cumulatively treated between June 2008 and December 2012 qualified for study inclusion, each undergoing total-gland cryoablation for prostate cancer. The degree of saturated prostate cryoablation was defined as the average prostate volume per cryoprobe (APVC), and divided into four groups (groups 1-4: < 3 ml, 3 to < 4 ml, 4 to < 5 ml, a parts per thousand 5 ml, respectively). Post-ablative complications were measured prospectively at weeks 1, 2, 4, 8, 12, and 24 by using the Common Terminology Criteria for Adverse Events. Biochemical failure was gauged by Phoenix criterion. The Kruskal-Wallis rank sum test and Chi-square test were used to compare clinical characteristics of therapeutic subsets. The Cox proportional hazard model was applied for comparison of recurrence risk between groups. APVC group 1 had the highest pre-operative PSA value and smallest prostate size among the groups. Multivariate analysis of risks of biochemical failures revealed that the larger the APVC, the higher the hazard (p for trend = 0.01). Compared to the group 1 patients, the hazard ratios of biochemical failures in groups 2-4 were 4.4 (confidence interval (CI): 0.5-37), 8.8 (CI 1.1-73), and 9.4 (CI 1.1-78), respectively. Nevertheless, the complication rate of APVC group 1 patients was similar to the other three groups. Saturated prostate cryoablation by reducing APVC would be beneficial for cancer control without compromising patient safety.
引用
收藏
页码:1487 / 1494
页数:8
相关论文
共 19 条
[1]  
[Anonymous], 2009, NIH Publ, P0
[2]   Best Practice Statement on Cryosurgery for the Treatment of Localized Prostate Cancer [J].
Babaian, Richard J. ;
Donnelly, Bryan ;
Bahn, Duke ;
Baust, John G. ;
Dineen, Martin ;
Ellis, David ;
Katz, Aaron ;
Pisters, Louis ;
Rukstalis, Daniel ;
Shinohara, Katsuto ;
Thrasher, J. Brantley .
JOURNAL OF UROLOGY, 2008, 180 (05) :1993-2004
[3]   Proactive rectal warming during total-gland prostate cryoablation [J].
Chen, Chung-Hsin ;
Pu, Yeong-Shiau .
CRYOBIOLOGY, 2014, 68 (03) :431-435
[4]   Ten-year biochemical disease control for patients with prostate cancer treated with cryosurgery as primary therapy [J].
Cohen, Jeffrey K. ;
Miller, Ralph J., Jr. ;
Ahmed, Sharmila ;
Lotz, Meredith J. ;
Baust, John .
UROLOGY, 2008, 71 (03) :515-518
[5]   Androgen suppression and radiation vs radiation alone for prostate cancer - A randomized trial [J].
D'Amico, Anthony V. ;
Chen, Ming-Hui ;
Renshaw, Andrew A. ;
Loffredo, Marian ;
Kantoff, Philip W. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (03) :289-295
[6]  
Dhar N, 2011, BJU INT, V108, P508, DOI 10.1111/j.1464-410X.2011.10238.x
[7]   NEOADJUVANT HORMONAL DOWNSIZING OF LOCALIZED CARCINOMA OF THE PROSTATE - EFFECTS ON THE VOLUME OF NORMAL TISSUE IRRADIATION [J].
FORMAN, JD ;
KUMAR, R ;
HAAS, G ;
MONTIE, J ;
PORTER, AT ;
MESINA, CF .
CANCER INVESTIGATION, 1995, 13 (01) :8-15
[8]   Does Neoadjuvant Androgen Deprivation Therapy Before Primary Whole Gland Cryoablation of the Prostate Affect the Outcome? [J].
Grossgold, Erik ;
Given, Robert ;
Ruckle, Herbert ;
Jones, J. Stephen .
UROLOGY, 2014, 83 (02) :379-384
[9]   Whole gland primary prostate cryoablation: Initial results from the Cryo On-Line Data Registry [J].
Jones, J. Stephen ;
Rewcastle, John C. ;
Donnelly, Bryan J. ;
Lugnani, Franco M. ;
Pisters, Louis L. ;
Katz, Aaron E. .
JOURNAL OF UROLOGY, 2008, 180 (02) :554-558
[10]   Definition of Biochemical Success Following Primary Whole Gland Prostate Cryoablation [J].
Levy, David A. ;
Ross, Ashley E. ;
ElShafei, Ahmed ;
Krishnan, Nirmal ;
Hatem, Asmaa ;
Jones, J. Stephen .
JOURNAL OF UROLOGY, 2014, 192 (05) :1380-1384