Palladium-Catalyzed α-Arylation of Benzylic Phosphonates

被引：45
|
作者：
Montel, Sonia [1 ]
Raffier, Ludovic [1 ]
He, Yuying [1 ]
Walsh, Patrick J. [1 ]
机构：
[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Penn Merck Lab High Throughput Expt, Philadelphia, PA 19104 USA
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 05期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
CARBANIONS; SULFOXIDES; COMPLEXES; AMIDES;
D O I：
10.1021/ol5002413
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)(2)/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%).
引用
收藏
页码：1446 / 1449
页数：4
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