Lymphatics as a New Active Player in Reverse Cholesterol Transport

被引：6

作者：

Kahn, Mark L. ^{[1
,2
]}

Rader, Daniel J. ^{[1
,2
]}

机构：

[1] Univ Penn, Cardiovasc Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA

来源：

CELL METABOLISM | 2013年 / 17卷 / 05期

关键词：

D O I：

10.1016/j.cmet.2013.04.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reverse cholesterol transport (RCT), a key function of high-density lipoproteins (HDL), prevents excess cholesterol in tissues. A study in this issue (Lim et al., 2013) suggests that lymphatic vessels are critical for normal RCT and mediate the active trans-endothelial transport of HDL via the HDL receptor SR-BI.

引用

页码：627 / 628

页数：2

共 10 条

[1] Novel HDL-directed pharmacotherapeutic strategies [J].

Degoma, Emil M. ;

Rader, Daniel J. .

NATURE REVIEWS CARDIOLOGY, 2011, 8 (05) :266-277

[2] Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity [J].

Harvey, NL ;

Srinivasan, RS ;

Dillard, ME ;

Johnson, NC ;

Witte, MH ;

Boyd, K ;

Sleeman, MW ;

Oliver, G .

NATURE GENETICS, 2005, 37 (10) :1072-1081

[3] Lymphatic Vessels Are Essential for the Removal of Cholesterol from Peripheral Tissues by SR-BI-Mediated Transport of HDL [J].

Lim, Hwee Ying ;

Thiam, Chung Hwee ;

Yeo, Kim Pin ;

Bisoendial, Radjesh ;

Hii, Chung Shii ;

McGrath, Kristine C. Y. ;

Tan, Kar Wai ;

Heather, Alison ;

Alexander, J. Steven Jonathan ;

Angeli, Veronique .

CELL METABOLISM, 2013, 17 (05) :671-684

[4] Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration [J].

Lim, Hwee Ying ;

Rutkowski, Joseph M. ;

Helft, Julie ;

Reddy, Sai T. ;

Swartz, Melody A. ;

Randolph, Gwendalyn J. ;

Angeli, Veronique .

AMERICAN JOURNAL OF PATHOLOGY, 2009, 175 (03) :1328-1337

[5] Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques [J].

Llodrá, J ;

Angeli, V ;

Liu, JH ;

Trogan, E ;

Fisher, EA ;

Randolph, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11779-11784

[6] The not-so-simple HDL story Is it time to revise the HDL cholesterol hypothesis? [J].

Rader, Daniel J. ;

Tall, Alan R. .

NATURE MEDICINE, 2012, 18 (09) :1344-1346

[7] The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis [J].

Rader, Daniel J. ;

Alexander, Eric T. ;

Weibel, Ginny L. ;

Billheimer, Jeffrey ;

Rothblat, George H. .

JOURNAL OF LIPID RESEARCH, 2009, 50 :S189-S194

[8] Secondary lymphedema in the mouse tail: Lymphatic hyperplasia, VEGF-C upregulation, and the protective role of MMP-9 [J].

Rutkowski, Joseph M. ;

Moya, Monica ;

Johannes, Jimmy ;

Goldman, Jeremy ;

Swartz, Melody A. .

MICROVASCULAR RESEARCH, 2006, 72 (03) :161-171

[9]

SCHIRGER A, 1962, JAMA, V182, P14

[10]

SLOOP CH, 1987, J LIPID RES, V28, P225

← 1 →