Cholesteryl Ester Transfer Protein Inhibitors as Agents to Reduce Coronary Heart Disease Risk

被引：14

作者：

Barter, Philip J. ^{[1
]}

Rye, Kerry-Anne ^{[1
]}

机构：

[1] Univ New South Wales, Sch Med Sci, Sydney, NSW 2052, Australia

来源：

CARDIOLOGY CLINICS | 2018年 / 36卷 / 02期

关键词：

Cholesteryl ester transfer protein; Inhibitor; High density lipoprotein; Atherosclerotic cardiovascular disease; Clinical trial; HIGH-DENSITY-LIPOPROTEINS; LIPID-LEVEL MANAGEMENT; RANDOMIZED CLINICAL-TRIAL; EVENTS ILLUMINATE TRIAL; TRANSGENIC MICE; CETP GENE; ATTENUATES ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION; ENDOTHELIAL FUNCTION; PLASMA-LIPOPROTEINS;

D O I：

10.1016/j.ccl.2017.12.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters from the nonatherogenic high-density lipoprotein (HDL) fraction to potentially proatherogenic non-HDL fractions. Inhibition of CETP reduces the concentration of non-HDL cholesterol, enhances HDL functionality, and increases the concentration of HDL cholesterol and apoA-I. Despite an absence of benefit in earlier trials of CETP inhibition, the REVEAL trial has shown that treatment with the CETP inhibitor anacetrapib reduces the risk of having a coronary event in high-risk, statin-treated patients.

引用

页码：299 / +

页数：13

共 69 条

[1] Lessons Learned from the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) Trial [J].

Barter, Philip .

AMERICAN JOURNAL OF CARDIOLOGY, 2009, 104 (10A) :10E-15E

[2] Effects of torcetrapib in patients at high risk for coronary events [J].

Barter, Philip J. ;

Caulfield, Mark ;

Eriksson, Mats ;

Grundy, Scott M. ;

Kastelein, John J. P. ;

Komajda, Michel ;

Lopez-Sendon, Jose ;

Mosca, Lori ;

Tardif, Jean-Claude ;

Waters, David D. ;

Shear, Charles L. ;

Revkin, James H. ;

Buhr, Kevin A. ;

Fisher, Marian R. ;

Tall, Alan R. ;

Brewer, Bryan .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (21) :2109-2122

[3] Cholesteryl ester transfer protein inhibition as a strategy to reduce cardiovascular risk [J].

Barter, Philip J. ;

Rye, Kerry-Anne .

JOURNAL OF LIPID RESEARCH, 2012, 53 (09) :1755-1766

[4] Effect of Torcetrapib on Glucose, Insulin, and Hemoglobin A1c in Subjects in the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) Trial [J].

Barter, Philip J. ;

Rye, Kerry-Anne ;

Tardif, Jean-Claude ;

Waters, David D. ;

Boekholdt, S. Matthijs ;

Breazna, Andrei ;

Kastelein, John J. P. .

CIRCULATION, 2011, 124 (05) :555-562

[5]

BARTER PJ, 1982, BIOCHEM J, V208, P1

[6] ACTIVITY OF AN ESTERIFIED CHOLESTEROL TRANSFERRING FACTOR IN HUMAN AND RAT SERUM [J].

BARTER, PJ ;

LALLY, JI .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 531 (02) :233-236

[7]

BARTER PJ, 1980, J LIPID RES, V21, P238

[8] Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease [J].

Besler, Christian ;

Heinrich, Kathrin ;

Rohrer, Lucia ;

Doerries, Carola ;

Riwanto, Meliana ;

Shih, Diana M. ;

Chroni, Angeliki ;

Yonekawa, Keiko ;

Stein, Sokrates ;

Schaefer, Nicola ;

Mueller, Maja ;

Akhmedov, Alexander ;

Daniil, Georgios ;

Manes, Costantina ;

Templin, Christian ;

Wyss, Christophe ;

Maier, Willibald ;

Tanner, Felix C. ;

Matter, Christian M. ;

Corti, Roberto ;

Furlong, Clement ;

Lusis, Aldons J. ;

von Eckardstein, Arnold ;

Fogelman, Alan M. ;

Luescher, Thomas F. ;

Landmesser, Ulf .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (07) :2693-2708

[9] Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial [J].

Bots, Michiel L. ;

Visseren, Frank L. ;

Evans, Gregory W. ;

Riley, Ward A. ;

Revkin, James H. ;

Tegeler, Charles H. ;

Shear, Charles L. ;

Duggan, William T. ;

Vicari, Ralph M. ;

Grobbee, Diederick E. ;

Kastelein, John J. .

LANCET, 2007, 370 (9582) :153-160

[10] MOLECULAR-BASIS OF LIPID TRANSFER PROTEIN-DEFICIENCY IN A FAMILY WITH INCREASED HIGH-DENSITY LIPOPROTEINS [J].

BROWN, ML ;

INAZU, A ;

HESLER, CB ;

AGELLON, LB ;

MANN, C ;

WHITLOCK, ME ;

MARCEL, YL ;

MILNE, RW ;

KOIZUMI, J ;

MABUCHI, H ;

TAKEDA, R ;

TALL, AR .

NATURE, 1989, 342 (6248) :448-451

← 1 2 3 4 5 6 7 →