Effects of aging on motor cortex excitability

被引：236
作者：
Oliviero, A
Profice, P
Tonali, PA
Pilato, F
Saturno, E
Dileone, M
Ranieri, F
Di Lazzaro, V
机构：
[1] Hosp Nacl Paraplej, FENNSI Grp, SESCAM, Toledo 45071, Spain
[2] Univ Cattolica Rome, Neurol Inst, I-00168 Rome, Italy
来源：
NEUROSCIENCE RESEARCH | 2006年 / 55卷 / 01期
关键词：
aging; transcranial magnetic stimulation; GABA; motor cortex;
D O I：
10.1016/j.neures.2006.02.002
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To determine whether aging is associated with changes in excitability of the cerebral cortex, we evaluated the excitability of the motor cortex with transcranial magnetic stimulation (TMS). We compared TMS related measures obtained in a group of young people with those of a group of old people. Motor evoked potential (MEP) amplitude was significantly smaller in older than in younger controls (1.3 +/- 0.8 mV versus 2.7 +/- 1.1 mV; p < 0.0071). Mean cortical silent period (CSP) duration was shorter in older than in younger controls (87 +/- 29 ms versus 147 +/- 39 ins; p < 0.0071). SP duration/MEP amplitude ratios were similar in both groups. Our results are consistent with an impaired efficiency of some intracortical circuits in old age. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
引用
收藏
页码：74 / 77
页数：4
相关论文
共 20 条
[1]  
[Anonymous], ELECTRODIAGNOSIS DIS
[2]   Direct demonstration of the effect of lorazepam on the excitability of the human motor cortex [J].
Di Lazzaro, V ;
Oliviero, A ;
Meglio, M ;
Cioni, B ;
Tamburrini, G ;
Tonali, P ;
Rothwell, JC .
CLINICAL NEUROPHYSIOLOGY, 2000, 111 (05) :794-799
[3]   Noninvasive in vivo assessment of cholinergic cortical circuits in AD using transcranial magnetic stimulation [J].
Di Lazzaro, V ;
Oliviero, A ;
Tonali, PA ;
Marra, C ;
Daniele, A ;
Profice, P ;
Saturno, E ;
Pilato, F ;
Masullo, C ;
Rothwell, JC .
NEUROLOGY, 2002, 59 (03) :392-397
[4]  
DILAZZARO V, 1995, ELECTROMYOGR MOTOR C, V97, P259
[5]   Cortical projections to spinal motoneurons: Changes with aging and amyotrophic lateral sclerosis [J].
Eisen, A ;
EntezariTaher, M ;
Stewart, H .
NEUROLOGY, 1996, 46 (05) :1396-1404
[6]   Transcranial magnetic stimulation and the human brain [J].
Hallett, M .
NATURE, 2000, 406 (6792) :147-150
[7]  
HORTOBAGYI T, 2005, EXP BRAIN RES, P1
[8]   Influences of aging, gender, and handedness on motor performance of upper and lower extremities [J].
Kauranen, K ;
Vanharanta, H .
PERCEPTUAL AND MOTOR SKILLS, 1996, 82 (02) :515-525
[9]   CORTICOCORTICAL INHIBITION IN HUMAN MOTOR CORTEX [J].
KUJIRAI, T ;
CARAMIA, MD ;
ROTHWELL, JC ;
DAY, BL ;
THOMPSON, PD ;
FERBERT, A ;
WROE, S ;
ASSELMAN, P ;
MARSDEN, CD .
JOURNAL OF PHYSIOLOGY-LONDON, 1993, 471 :501-519
[10]   The cortical silent period: intrinsic variability and relation to the waveform of the transcranial magnetic stimulation pulse [J].
Orth, M ;
Rothwell, JC .
CLINICAL NEUROPHYSIOLOGY, 2004, 115 (05) :1076-1082
12