Screening of the human tumor necrosis factor-alpha (TNF-α) gene promoter polymorphisms by PCR-DGGE analysis

被引：12

作者：

Patiño-García, A

Sotillo-Piñeiro, E

Modesto, C

Sierrasesúmaga, L

机构：

[1] Univ Navarra, Univ Clin, Dept Paediat, E-31080 Pamplona, Spain

[2] Hosp Gen Valle Hebron, Dept Internal Med, Barcelona, Spain

来源：

MUTATION RESEARCH-GENOMICS | 1999年 / 406卷 / 2-4期

关键词：

PCR; DGGE; polymorphism; TNF-alpha;

D O I：

10.1016/S1383-5726(99)00004-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have designed a new PCR-DGGE technique that enables detection of base changes in the TNF-alpha gene promoter. Screening of 130 samples from Spanish children has shown that this technique accurately detects the altered band patterns induced by the presence of the polymorphisms at positions -376, -308, -238 and -163 of the promoter sequence. Although further analysis are needed to fully characterise the alterations detected, we believe that this PCR-DGGE technique is a rapid and sensitive first approach to the genetic characterisation of the TNF-alpha promoter. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：121 / 125

页数：5

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