Sarcomatoid carcinoma of small intestine:: diagnostic problems raised by an unusual tumor

Sarcomatoid carcinomas involving the intestinal tract are rare and useful associated with poor prognosis. We report a case of sarcomatoid carcinoma of the ileum diagnosed in a 61-year-old man The patient presented with acute intestinal occlusion. Surgical resection of the ileum was performed. At macroscopic examination, two large polypoid mosses were found. Frozen section examination suggested the diagnosis of malignant stromal tumor At histological examination, both tumors were formed by pleiomorphic, large spindle cells, presenting numerous mitoses and marked nuclear atypia Immunohistochemical examination showed that tumor cells coexpressed vimentin and epithelial markers (cytokeratins, EMA). The final diagnosis was monomorphic sarcomatoid carcinoma. The patient deceased with metastatic disease after 3 months of follow-up. This report underlines the potential diagnostic problems raised by this unusual type of carcinoma and emphasizes the role of immunohistochemistry in assessing the correct diagnosis.