Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson's Disease

被引：219

作者：

Zhu, Zhou ^{[1
]}

Yang, Chuanbin ^{[1
]}

Iyaswamy, Ashok ^{[1
]}

Krishnamoorthi, Senthilkumar ^{[1
]}

Sreenivasmurthy, Sravan Gopalkrishnashetty ^{[1
]}

Liu, Jia ^{[1
]}

Wang, Ziying ^{[1
]}

Tong, Benjamin Chun-Kit ^{[1
]}

Song, Juxian ^{[2
]}

Lu, Jiahong ^{[3
]}

Cheung, King-Ho ^{[1
]}

Li, Min ^{[1
]}

机构：

[1] Hong Kong Baptist Univ, Sch Chinese Med, Mr & Mrs Ko Chi Ming Ctr Parkinsons Dis Res, Hong Kong 999077, Peoples R China

[2] Guangzhou Univ Chinese Med, Med Coll Acupuncture Moxibust & Rehabil, Guangzhou 510006, Guangdong, Peoples R China

[3] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macau, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

mTOR; autophagy; Parkinson's disease; DOPA-INDUCED DYSKINESIA; CELL-CYCLE ARREST; MAMMALIAN TARGET; IN-VITRO; DOPAMINERGIC-NEURONS; MEDIATED AUTOPHAGY; BINDING PARTNER; DOWN-REGULATION; RAPAMYCIN; COMPLEX;

D O I：

10.3390/ijms20030728

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the activity of the unc51-like kinase 1 (ULK1) complex and vacuolar protein sorting 34 (VPS34) complex, and the intracellular distribution of TFEB/TFE3 and proto-lysosome tubule reformation. Parkinson's disease (PD) is a serious, common neurodegenerative disease characterized by dopaminergic neuron loss in the substantia nigra pars compacta (SNpc) and the accumulation of Lewy bodies. An increasing amount of evidence indicates that mTOR and autophagy are critical for the pathogenesis of PD. In this review, we will summarize recent advances regarding the roles of mTOR and autophagy in PD pathogenesis and treatment. Further characterizing the dysregulation of mTOR pathway and the clinical translation of mTOR modulators in PD may offer exciting new avenues for future drug development.

引用

页数：15

共 115 条

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