Beryllium binding to adenosine 5'-phosphates in aqueous solution at 25C

被引：7

作者：

Alderighi, Lucia ^{[1
]}

Dominguez, Sixto ^{[2
]}

Gans, Peter ^{[3
]}

Midollini, Stefano ^{[4
]}

Sabatini, Antonio ^{[1
]}

Vacca, Alberto ^{[1
]}

机构：

[1] Univ Firenze, Dept Chem, Sesto Fiorentino, Italy

[2] Univ La Laguna, Dept Inorgan Chem, Tenerife, Canary Islands, Spain

[3] Proton Software, Leeds, W Yorkshire, England

[4] ICCOM CNR, Sesto Fiorentino, Italy

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2009年 / 62卷 / 01期

关键词：

Beryllium; Nucleotides; Formation constants; COMPLEX-FORMATION; EQUILIBRIA; HYDROLYSIS; CONSTANTS; ATP; CHEMISTRY; MALONATE; FLUORIDE; OXALATE; IONS;

D O I：

10.1080/00958970802474862

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Equilibrium constants for the binding of beryllium(II) to the nucleotides: adenosine 5'-monophosphate, -diphosphate, and -triphosphate have been determined. The species formed are [BeL](z-2)-, [Be(HL)](z-3)-, [Be2(OH)L2](2z-3)- and [Be3(OH)3(HL)3](3z-6)-, where Lz- represents the fully deprotonated nucleotide. When the complex contains a protonated ligand, the protonation site is an adenosine nitrogen. Formation of these complexes is unlikely to interfere, under physiological conditions, with the functioning of the nucleotides due to the precipitation of beryllium hydroxide in the pH range 6-7.

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页码：14 / 22

页数：9

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