Solid-phase synthesis of 1,3,4-oxadiazoline-5-thione derivatives from resin-bound acylhydrazines

被引：21

作者：

Liu, ZX ^{[1
]}

Zhao, JL ^{[1
]}

Huang, X ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 07期

基金：

中国国家自然科学基金;

关键词：

substituted 1,3,4-oxadiazoles; solid-phase synthesis; acylhydrazines;

D O I：

10.1016/j.bmcl.2006.01.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new strategy for solid-phase synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. The 1,3,4-oxadiazoline-5-thione derivatives were synthesized from resin-bound acylhydrazines in several steps providing 78-88% overall yields and excellent purity. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1828 / 1830

页数：3

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