Protective role of the vitamin D receptor

被引：108

作者：

Yang, Lina ^{[1
]}

Ma, Jianfei ^{[1
]}

Zhang, Xiuli ^{[1
]}

Fan, Yi ^{[1
]}

Wang, Lining ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Nephrol, Shenyang 110001, Liaoning, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2012年 / 279卷 / 02期

关键词：

Vitamin D receptor; 1,25(OH)(2)D-3; Protective; Anti-inflammation; Proteinuria; Anti-fibrosis; 3RD NATIONAL-HEALTH; DENDRITIC CELL MODULATION; SERUM 25-HYDROXYVITAMIN D; PRIMARY BILIARY-CIRRHOSIS; INDUCED KIDNEY INJURY; 1,25-DIHYDROXYVITAMIN D-3; T-CELLS; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; COMBINATION THERAPY; GENE POLYMORPHISMS;

D O I：

10.1016/j.cellimm.2012.10.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vitamin D receptor (VDR) is found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney. The nonclassic actions are therefore potential targets for the active metabolite of vitamin D, 1,25(OH)(2)D-3. This review is intended to highlight the actions of VDR in role of protection. Medline is searched for articles describing actions of VDR on secondary hyperparathyroidism, diabetic nephropathy, hypertension and atherosclerosis. VDR exerts its protective activities through the following mechanisms: inhibition of renin-angiotensin system (RAS); regulation of proliferation and differentiation; reduction of proteinuria; anti-inflammation and anti-fibrosis. The nonclassic actions of VDR provide a number of potential new clinical applications for 1,25(OH)(2)D-3 and its analogs. We believe 1,25(OH)(2)D-3/VDR can be of particular value in the prevention of kidney-related diseases. Crown Copyright (c) 2012 Published by Elsevier Inc. All rights reserved.

引用

页码：160 / 166

页数：7

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