Interaction of Guanine with [Cu(II)(Salgly)H2O] and [Cu(II)(Salhis)H2O]: UV/Visible, Fluorescence and Electrochemical studies

Metal atoms and metal complexes can coordinate to electron donor groups of the nucleo bases and thereby influence the canonical DNA structures propagating the formation of mispairs of DNA. Guanine is an important nucleo base and its coordination behaviour with copper complexes [Cu(II)(Salgly)H2O] and [Cu (II)(Salhis)H2O] have been studied by various spectroscopic and electrochemical techniques. One guanine is found to bind to the complexes with high binding constant. Guanine binding makes the redox potential of Cu(II)/Cu(I) couple shifted towards negative direction. In cationic and anionic charged environment, provided by surfactant micelles, redox potential of the Cu(II)/Cu(I) couple was found to shift in positive (by 0.050 V) and in negative (by 0.025 V) direction.