Pyroptosis-Related Gene Signature Predicts the Prognosis of ccRCC Using TCGA and Single-Cell RNA Seq Database

被引：3

作者：

Gan, Ying ^{[1
]}

Zhang, Zhenan ^{[1
]}

Wang, Xiaofei ^{[1
]}

Li, Aolin ^{[1
]}

Fan, Yu ^{[1
]}

Zhang, Qian ^{[1
]}

机构：

[1] Peking Univ First Hosp, Dept Urol, Beijing 100034, Peoples R China

来源：

JOURNAL OF HEALTHCARE ENGINEERING | 2022年 / 2022卷

基金：

中国国家自然科学基金;

关键词：

CANCER; INFLAMMASOME; ACTIVATION; EXPRESSION; CARCINOMA; PATHWAY; DEATH;

D O I：

10.1155/2022/8224618

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of renal carcinoma, which is not sensitive to both radiotherapy and chemotherapy. The objective response rate of metastatic renal cancer to targeted drugs and immunotherapy is unsatisfactory. Pyroptosis, proven as an inflammatory form of programmed cell death, could be activated by some inflammasomes, while could create a tumor-suppressing environment by releasing inflammatory factors in the tumor. To explore indicators predicting the prognosis of ccRCC and the effect of antitumor therapy, we constructed a pyroptosis risk model containing 4 genes after 11 pyroptosis-related genes of 516 ccRCC cases in the TCGA database were scanned. Based on the risk score, 516 ccRCC cases were divided into two groups for functional enrichment analysis and immune profile to seek functional pathways and potential therapeutic targets. Besides, those results were verified in GSE29609 and single-cell transcriptomic data. The study suggests that the conducted pyroptosis model could predict the prognosis of ccRCC and reflect the immune microenvironment, which may help in immune checkpoint inhibitor treatment.

引用

页数：12

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