Mechanistically Inspired Catalysts for Enantioselective Desymmetrizations by Olefin Metathesis

被引：38

作者：

Fournier, Pierre-Andre ^{[1
]}

Savoie, Jolaine ^{[1
]}

Stenne, Brice ^{[1
]}

Bedard, Marion ^{[1
]}

Grandbois, Alain ^{[1
]}

Collins, Shawn K. ^{[1
]}

机构：

[1] Univ Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 28期

基金：

加拿大自然科学与工程研究理事会;

关键词：

asymmetric catalysis; desymmetrization; N-heterocyclic carbenes; olefin metathesis; ruthenium;

D O I：

10.1002/chem.200800642

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In asymmetric olefin metathesis reactions, the addition of halide additives is often required to augment enantioselectivities, despite the fact that the additives result in catalysts with diminished reactivities. The preparation of new chiral Ru-based catalysts was accomplished by exploiting previously reported mechanistic studies. The catalysts possess a high level of reactivity and successfully induce high levels of asymmetry in desymmetrization reactions without the use of halide additives.

引用

页码：8690 / 8695

页数：6

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