Structural, enzyme inhibition, antibacterial and DNA protection studies of organotin(IV) derivatives of thiophene-2-carboxylic acid

被引：29

作者：

Abbas, Saghir ^{[1
]}

Hussain, Mukhtiar ^{[1
]}

Ali, Saqib ^{[1
]}

Parvez, Masood ^{[2
]}

Raza, Ahsan ^{[3
]}

Haider, Ali ^{[1
,4
]}

Iqbal, Jamshed ^{[3
]}

机构：

[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[2] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada

[3] COMSATS Inst Informat Technol, Dept Pharmaceut Sci, Abbottabad 22060, Pakistan

[4] Jacob Univ, Sch Sci & Engn, D-28725 Bremen, Germany

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2013年 / 724卷

关键词：

Thiophene-2-carboxylic acid; Organotin(IV); Spectroscopy; X-ray crystallography; Biological screening; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURE; COMPLEXES; CHEMISTRY; CLEAVAGE; AGENTS;

D O I：

10.1016/j.jorganchem.2012.11.033

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of five monomeric and polymeric complexes: [Bu3Sn(C5H4O2S)] (1), [Me3Sn(C5H4O2S)] (2), [Cy3Sn(C5H4O2S)] (3), [Bu2Sn(C5H4O2S)(2)] (4), [Oct(2)Sn(C5H4O2S)(2)] (5) of thiophene-2-carboxylic acid have been synthesized by the reaction of ligand acid with di- organotin compounds for the complexes 4, 5 and its sodium salt with tri-organotin compounds for the complexes 1, 2 and 3 respectively, in suitable stoichiometries. All complexes have been structurally characterized by vibrational and magnetic resonance (H-1, C-13 NMR) spectroscopies. The structures of complexes (2), (3) and (4) have also been elucidated by X-ray crystallography. Relative potential has been assessed for their anti-bacterial, DNA protection and inhibitory assay against acetyl cholinesterase and butyryl cholinesterase. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：255 / 261

页数：7

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