Physicochemical characterization of a hydrophilic model drug-loaded PHBV microparticles obtained by the double emulsion/solvent evaporation technique

被引：45

作者：

Farago, Paulo V. ^{[2
]}

Raffin, Renata P. ^{[3
]}

Pohlmann, Adriana R. ^{[4
]}

Guterres, Silvia S. ^{[3
]}

Zawadzki, Sonia F. ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Quim, BR-81531990 Curitiba, Parana, Brazil

[2] Univ Estadual Ponta Grossa, Dept Ciencias Farmaceut, BR-84030900 Ponta Grossa, PR, Brazil

[3] Univ Fed Rio Grande do Sul, Fac Farm, Dept Prod & Control Med, BR-9061000 Porto Alegre, RS, Brazil

[4] Univ Fed Rio Grande do Sul, Inst Quim, Dept Quim Organ, BR-91501970 Porto Alegre, RS, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2008年 / 19卷 / 07期

关键词：

PHBV; double emulsion/solvent evaporation technique; hydrophilic model drug; microparticles;

D O I：

10.1590/S0103-50532008000700011

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) microparticles containing a water-soluble model drug, metformin hydrochloride (MH), were obtained by a double emulsion/solvent evaporation technique. Several formulations were prepared in order to investigate the influence of each composition on the encapsulation efficiency (EE). The highest value of EE (9.76%) was obtained using simultaneously pH alkalinization and NaCl addition in the external water phase of the formulation. SEM study revealed a spherical morphology and a rough surface. The crystalline diffraction intensities for the MH-loaded microparticles were lower than that verified for the physical mixture. FTIR results suggested that no chemical bond between the polymer and the drug was formed. Also thermal analyses indicated a favorable interaction between MH and PHBV. In vitro drug release demonstrated the influence of the PHBV on the dissolution profile of MH.

引用

页码：1298 / 1305

页数：8

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