One-Step Cyclization: Synthesis of N-Heteroalkyl-N′ -tosylpiperazines

被引:10
作者
Huang, Jianying [1 ]
Xu, Weiyuan [1 ]
Xie, Hujun [1 ]
Li, Shijun [2 ]
机构
[1] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310035, Zhejiang, Peoples R China
[2] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
PIPERAZINE; DERIVATIVES; DENSITY;
D O I
10.1021/jo3012896
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Piperazine derivatives are important intermediates in organic synthesis and useful building blocks in pharmaceutical and fine chemical industries. Currently available synthetic routes for these heterocyclic compounds have limited scope owing to the harsh reaction conditions, low yields, and multistep process. Herein, we reported a practical method for synthesis of alkyl-, alcohol-, amine-, and ester-extended tosylpiperazines under mild conditions with moderate to high yields. This protocol exhibits potential applicability in the synthesis of pharmaceuticals and natural products because of the operational simplicity and the conveniently available reactants. On the basis of the experimental and theoretical results, a plausible mechanism of aliphatic nucleophilic substitution (S-N) in the cyclization has been postulated and evidence for the formation of a six-membered ring has also been confirmed by means of density functional theory (DFT) calculations.
引用
收藏
页码:7506 / 7511
页数:6
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