Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives

被引：8

作者：

Nam, G

Kang, TW

Shin, JH

Choi, KI

机构：

[1] Korea Inst Sci & Technol, Biochem Res Ctr, Seoul, South Korea

[2] Seoul Natl Univ, Sch Chem & Mol Engn, Seoul 151742, South Korea

[3] Chong Kun Dang Corp, CKD Res Inst, Cheonan 330831, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 03期

关键词：

anti-Helicobacter pylori; erythromycin; oxime ether; MIC; acid stability;

D O I：

10.1016/j.bmcl.2005.10.045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and anti-Helicobacter pylori (H. pylori) activity evaluation of a new series of erythromycin A (E)-9-oxime ether derivatives are described. These compounds exhibited comparable in vitro anti-H. pylori activity and improved acid stability compared to the reference compound clarithromycin. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：569 / 572

页数：4

共 16 条

[1] ANTIBACTERIAL ACTIVITY OF ROXITHROMYCIN - A LABORATORY EVALUATION [J].