Neuroprotective effects of triterpenoid saponins from Medicago sativa L. against H2O2-induced oxidative stress in SH-SY5Y cells

被引：19
作者：
Liu, Xue-Gui [1 ,2 ]
Sun, Yu-Qiu [1 ]
Bian, Jun [1 ]
Han, Ting [1 ]
Yue, Dan-Dan [1 ]
Li, Dan-Qi [1 ,2 ]
Gao, Pin-Yi [1 ,2 ]
机构：
[1] Shenyang Univ Chem Technol, Coll Pharmaceut & Biol Engn, Shenyang 110142, Liaoning, Peoples R China
[2] Shenyang Univ Chem Technol, Inst Funct Mol, Shenyang 110142, Liaoning, Peoples R China
来源：
BIOORGANIC CHEMISTRY | 2019年 / 83卷
基金：
中国国家自然科学基金;
关键词：
Medicago sativa L; Triterpenoid saponins; Neuroprotective effects; SH-SY5Y cells; GLYCOSIDES; AUTOPHAGY; FRUITS; ROOT;
D O I：
10.1016/j.bioorg.2018.11.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Medicago sativa L. is a forage legume plant widely distributed in all continents. Six new triterpenoid saponins, Medicagosides A-F (1-6) and five known ones (7-11) were isolated from M. sativa. Their structures were determined via HRESIMS, 1D and 2D NMR analysis. Biologically, all the isolates displayed neuroprotective activities against H2O2-induced damage in SH-SY5Y cells. Among them, compounds 1, 3-5 and 10 exhibited striking neuroprotective activities at 100 mu M, restoring cell viability range from 79.66% to 89.03%, relative to 79.46% (100 mu M) of Trolox used as the positive control.
引用
收藏
页码：468 / 476
页数：9
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