Recent advances in the chemistry of aminocyclitols

被引：52
作者：
Degado, Antonio [1 ,2 ]
机构：
[1] IIQAB CSIC, RUBAM, Dept Quim Organ Biol, Barcelona 08034, Spain
[2] Univ Barcelona, Fac Farm, Unitat Quim Farmaceut Unitat Associada CSIC, E-08028 Barcelona, Spain
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 23期
关键词：
aminocyclitols; cyclitols; natural products; synthetic methodology; stereocontrol; disatereoselectivity; functional group interconversion;
D O I：
10.1002/ejoc.200800238
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Aminocyclitols are a group of natural products with remarkable biological activities. Over the last years, significant efforts have been made to develop synthetic methodologies directed not only towards their total synthesis but also towards the design of structural analogues with improved or novel biological properties. The aim of this review is to provide the reader with a concise update of the most relevant methods for the synthesis of aminocyclitols described in the literature. The review is organized according to the methodologies used for the construction of the aminocyclitol framework. These methodologies include chemoenzymatic approaches, intramolecular cyclizations, reactions of cyclitol derivatives with nitrogen nucleophiles, and rearrangement reactions. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
引用
收藏
页码：3893 / 3906
页数：14
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