Phthalocyanines: a new class of G-quadruplex-ligands with many potential applications

被引：97

作者：

Yaku, Hidenobu ^{[1
,2
,3
]}

Fujimoto, Takeshi ^{[1
,3
]}

Murashima, Takashi ^{[1
,3
]}

Miyoshi, Daisuke ^{[1
,3
]}

Sugimoto, Naoki ^{[1
,3
]}

机构：

[1] Konan Univ, FIBER, Chuo Ku, Kobe, Hyogo 6500047, Japan

[2] Panasonic Corp, Adv Technol Res Labs, Kyoto 6190237, Japan

[3] Konan Univ, Fac Frontiers Innovat Res Sci & Technol FIRST, Chuo Ku, Kobe, Hyogo 6500047, Japan

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 50期

关键词：

MOLECULAR CROWDING CONDITIONS; INTRAMOLECULAR G-QUADRUPLEX; HUMAN TELOMERIC SEQUENCE; ANTICANCER DRUG DESIGN; INHIBITS TUMOR-GROWTH; C-MYC PROMOTER; K+ SOLUTION; INTERACTIVE AGENTS; CATIONIC PORPHYRINS; DNA STRUCTURES;

D O I：

10.1039/c2cc31037f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A G-quadruplex is a four-stranded DNA structure featuring stacked guanine tetrads, G-quartets. Formation of a G-quadruplex in telomere DNA can inhibit telomerase activity; therefore, development of G-quadruplex-ligands, which induce and/or stabilize G-quadruplexes, has become an area of great interest. Phthalocyanine derivatives have substantial potential as high-affinity G-quadruplex-ligands because these planar chromophores are similar in size and shape to the G-quartets. Here, we focus on the latest findings on phthalocyanine derivatives as G-quadruplex-ligands, and discuss the mechanisms by which phthalocyanines bind to G-quadruplexes with high affinity and selectivity. We also discuss potential biomedical and organic electronic applications of phthalocyanines that are dependent on their photophysical properties.

引用

页码：6203 / 6216

页数：14

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