PEROXIDE PROCESSES AND BIOSYNTHESIS OF CHOLESTEROL DERIVATIVES IN RABBIT TISSUES AT ACUTE L-ARGININE-INDUCED PANCREATITIS AND ITS CORRECTION

The positive corrective effect of fed flaxseed oil on the condition of the pancreas in acute L-arginine-induced pancreatitis was shown, the development of which was assessed by the number of necrotized acinar epitheliocytes in the head and tail of the pancreas and the activity of lipase and a-amylase in blood plasma. Feeding sunflower oil does not show a similar corrective effect. The normalizing effect of fed flaxseed oil on the state of the antioxidant defense system in rabbits in acute L-arginine-induced pancreatitis, on the content of thiobarbituric acid-positive products and the activity of superoxide dismutase, catalase and glutathione peroxidases in blood. Feeding sunflower oil leads to a deterioration of the oxidative-prooxidant balance. The ability of fed flaxseed oil to prevent disorders of content of non-esterified and esterified cholesterol in blood plasma, liver and skeletal muscle of rabbits in acute L-arginine-induced pancreatitis has been established. Feeding sunflower oil under the above conditions impairs the lipid composition of rabbit tissues. The positive effect of fed flaxseed oil on the ratio of anti-inflammatory polyunsaturated fatty acids of the omega-3 family to proinflammatory polyunsaturated fatty acids of the omega-6 family in the fatty acid spectrum of esterified cholesterol in blood plasma, liver and skeletal muscle of rabbits in acute L-arginine-induced pancreatitis. The result of the fed sunflower oil action on the studied indicators is quite the opposite. In acute L-arginine-induced pancreatitis, feeding flaxseed oil stimulates the conversion of cholesterol to bile acids, 25-OH-vitamin D-3, testosterone, aldosterone and cortisol in rabbits. The stimulating ability of fed sunflower oil in this regard is less pronounced.