Mechanisms of controlled drug release from drug-eluting stents

被引:287
作者
Acharya, Ghanashyam
Park, Kinam [1 ]
机构
[1] Purdue Univ, Dept Pharmaceut, W Lafayette, IN 47906 USA
[2] Purdue Univ, Dept Biomed Engn, Sch Pharm, W Lafayette, IN 47906 USA
[3] Akina Inc, W Lafayette, IN 47906 USA
关键词
drug-eluting stents; restenosis controlled drag delivery; stent coating; biocompatibility;
D O I
10.1016/j.addr.2006.01.016
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The clinical importance of drug-eluting stents (DESs) has been demonstrated by their unparalleled success in preventing restenosis after stenting procedures. The magnitude of success is historic despite their short history. The Current DESs deliver a single drug aiming to prevent or minimize proliferation of smooth muscle cells. Since the restenosis process involves several different biological responses, the ability to deliver the right drugs at the right times is critical for further development of the second generation of DESs. As the type of drugs that can be delivered from DESs varies, it is imperative to understand the drug delivery mechanisms and the approaches available for drug coating oil the stents. The drug delivery mechanisms Of Current DESs that have been used clinically and under clinical trials are explained. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:387 / 401
页数:15
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