Fibrin-associated diffuse large B-cell lymphoma with plasmacytic differentiation: case report and literature review

被引:5
作者
Moreno Moreno, Esther [1 ]
Ferrer-Gomez, Ana [1 ]
Pian Arias, Hector [1 ]
Garcia Garcia, Irene [2 ]
Garcia-Cosio, Monica [1 ]
机构
[1] Hosp Univ Ramon y Cajal, Dept Pathol, Ctra Colmenar Viejo Km 9,100, Madrid 28034, Spain
[2] Hosp Univ Ramon y Cajal, Dept Haematol, Ctra Colmenar Viejo Km 9,100, Madrid 28034, Spain
关键词
Myxoma; Primary cardiac lymphoma; Fibrin-associated diffuse large B-cell lymphoma; Epstein-Barr virus; Case report; CHRONIC INFLAMMATION; ATRIAL-MYXOMA; FEATURES;
D O I
10.1186/s13000-020-01034-7
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
BackgroundPrimary cardiac lymphomas are extremely rare entities (<2% of cardiac tumours) and the most frequent histologic type is diffuse large B-cell lymphoma (DLBCL). Fibrin-associated DLBCL (FA-DLBCL) is a very unusual form of DLBCL associated with chronic inflammation, and only case reports and small series have been described. In the heart, it usually occurs in the context of a cardiac myxoma or cardiac prostheses and it is not bulk forming. These lymphomas frequently present with non-germinal center phenotype and are associated with Epstein-Barr virus (EBV) type III latency.Case presentationWe describe a case of FA-DLBCL arising in a cardiac myxoma, with plasmacytic differentiation and type I EBV latency.ConclusionsAlthough they are very rare, FA-DLBCLs should be known for their diagnostic difficulty, due to its unspecified clinical manifestations, and for their more favourable prognosis, sometimes even without additional treatment after surgical resection.
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页数:6
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