Ultrastructural Analysis of Kidney, Liver and Duodenum Isolated from Treated Rats with Ginkgo Biloba Extract and Effects of this Medicinal Plant on the Biodistribution of the Radiopharmaceutical Sodium Pertechnetate

被引：4

作者：

Farias Moreno, Silvana Ramos ^{[1
,2
]}

de Carvalho, Jorge Jose ^{[3
]}

Nascimento, Ana Lucia ^{[3
]}

Arnobio, Adriano ^{[1
]}

Olej, Beni ^{[1
]}

Timoteo, Margareth de Oliveira ^{[1
]}

de Araujo Caldas, Luiz Querino ^{[1
]}

Bernardo Filho, Mario ^{[2
]}

机构：

[1] Univ Fed Fluminense, BR-24030210 Niteroi, RJ, Brazil

[2] Univ Estado Rio de Janeiro, Dept Biofis & Biometria, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, Brazil

[3] Univ Estado Rio de Janeiro, Dept Histol & Embriol, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, Brazil

来源：

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY | 2008年 / 51卷

关键词：

Ginkgo biloba; technetium-99m; biodistribution; morphology; ultrastructure;

D O I：

10.1590/S1516-89132008000700030

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ginkgo biloba extract (EGb) has been used to treat memory and concentration deficits, acts as platelet activating factor antagonism and prevents against damages caused by free radicals. EGb is a standardized extract that contains 24% flavonoids and 6% terpenoids. The aim of this work was to evaluate the possible influence of an EGb on the ultrastructure of some organs isolated from rats and on the biodistribution of sodium pertechnetate ((TcO4Na)-Tc-99m). The animals were treated with EGb and after six days, received (TcO4Na)-Tc-99m. The organs were isolated and fixed for ultrastructural analysis. The results showed that EGb has modified the ultrastructure of kidney, liver and duodenum and altered the biodistribution of (TcO4Na)-Tc-99m (P<0.05). It is speculated that the substances present in the EGb could act directly or generate metabolites capable to promote changes on the biodistribution of (TcO4Na)-Tc-99m and on the morphology of organs at ultrastructural level.

引用

页码：185 / 190

页数：6

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