Dealing with Pervasive Transcription

被引：208
作者：
Jensen, Torben Heick [1 ]
Jacquier, Alain [2 ]
Libri, Domenico [3 ]
机构：
[1] Aarhus Univ, Ctr mRNP Biogenesis & Metab, Dept Mol Biol & Genet, DK-8000 Aarhus C, Denmark
[2] Inst Pasteur, CNRS, Unite Genet Interact Macromol, UMR 3525, F-75015 Paris, France
[3] CNRS, Ctr Genet Mol, UPR 3404, F-91190 Gif Sur Yvette, France
来源：
MOLECULAR CELL | 2013年 / 52卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
RNA-POLYMERASE-II; CRYPTIC UNSTABLE TRANSCRIPTS; NONCODING RNA; ANTISENSE TRANSCRIPTION; NUCLEAR EXOSOME; INTERGENIC TRANSCRIPTION; BIDIRECTIONAL PROMOTERS; DIVERGENT TRANSCRIPTION; GENE-EXPRESSION; TERMINATION;
D O I：
10.1016/j.molcel.2013.10.032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly found RNAs have functions and how many are byproducts of functional, or spurious, transcription events. Cells control the accumulation of many opportunistic transcripts by limiting their synthesis and by provoking their early transcription termination and decay. In this review, we use S. cerevisiae and mammalian cells as models to discuss the circumstances by which pervasive transcripts are produced and turned over. This ultimately relates to the likelihood, and potential mechanism, of molecular function.
引用
收藏
页码：473 / 484
页数：12
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