Regio- and stereospecific ring opening of 1,1-dialkyl-2-(aryloxymethyl)aziridinium salts by bromide

被引：61

作者：

D'hooghe, M

Van Speybroeck, V

Waroquier, M

De Kimpe, N ^{[1
]}

机构：

[1] Univ Ghent, Dept Organ Chem, Fac Biosci Engn, Ghent, Belgium

[2] Univ Ghent, Ctr Mol Modeling, Theoret Phys Lab, Ghent, Belgium

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 14期

关键词：

D O I：

10.1039/b518298k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantiomerically pure 2-(aryloxymethyl)aziridines are efficiently transformed into chiral N-(2-bromo-3-aryloxypropyl) amines via a regio- and stereospecific ring opening of the intermediate aziridinium salts, and the experimental results are rationalized on the basis of some high level ab initio calculations.

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收藏

页码：1554 / 1556

页数：3

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