Enhanced growth and osteogenic differentiation of MC3T3-E1 cells on Ti6Al4V alloys modified with reduced graphene oxide

被引：18
作者：
Li, Xiaojing [1 ]
Lin, Kaili [2 ]
Wang, Zuolin [1 ]
机构：
[1] Tongji Univ, Sch Stomatol, Shanghai Engn Res Ctr Tooth Restorat & Regenerat, Dept Oral Implant, Shanghai 200072, Peoples R China
[2] Tongji Univ, Sch Stomatol, Shanghai Engn Res Ctr Tooth Restorat & Regenerat, Shanghai 200072, Peoples R China
来源：
RSC ADVANCES | 2017年 / 7卷 / 24期
基金：
中国国家自然科学基金;
关键词：
MESENCHYMAL STEM-CELLS; TITANIUM IMPLANT SURFACE; BONE REGENERATION; DENTAL IMPLANT; BIOMEDICAL APPLICATIONS; STROMAL CELLS; PURE TITANIUM; OSSEOINTEGRATION; IMMOBILIZATION; DEPOSITION;
D O I：
10.1039/c6ra25832h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Graphene and its derivatives, including graphene oxide (GO) and reduced graphene oxide (rGO), have been considered as promising candidates in tissue regeneration. However, there is little information about their use as dental implant coating materials. In the present study, we fabricated an rGO coating on Ti6Al4V alloys. Then, the effect of the rGO coating on the growth and osteogenic differentiation of MC3T3-E1 cells was investigated. Cell culture results showed that the rGO coating apparently stimulated cell adhesion and proliferation, and enhanced the growth and osteogenic differentiation of MC3T3-E1 cells on Ti6Al4V implants. Our studies demonstrate that the rGO-Ti substrate appears to be biocompatible and has osteoinductive potential, which suggests that rGO might be a potential coating material for promoting the osteogenic properties of titanium alloy dental implants.
引用
收藏
页码：14430 / 14437
页数：8
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