Magnetic nanoparticles for drug delivery

被引：700

作者：

Dobson, J ^{[1
]}

机构：

[1] Keele Univ, Inst Sci & Technol Med, Stoke On Trent ST4 7QB, Staffs, England

来源：

DRUG DEVELOPMENT RESEARCH | 2006年 / 67卷 / 01期

关键词：

magnetic nanoparticles; drug targeting; drug delivery; cancer therapy;

D O I：

10.1002/ddr.20067

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Targeting specific sites in vivo for the delivery of therapeutic compounds presents a major obstacle to the treatment of many diseases. One targeted delivery technique that has gained prominence in recent years is the use of magnetic nanoparticles. In these systems, therapeutic compounds are attached to biocompatible magnetic nanoparticles and magnetic fields generated outside the body are focused on specific targets in vivo. The fields capture the particle complex resulting in enhanced delivery to the target site. This review will focus on technical aspects of magnetic targeting as well as nanoparticle design and animal and clinical trials.

引用

页码：55 / 60

页数：6

共 36 条

[11] Biodegradable nanoparticles for drug delivery and targeting [J].

Hans, ML ;

Lowman, AM .

CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE, 2002, 6 (04) :319-327

[12] Magnetite nanoparticle dispersions stabilized with triblock copolymers [J].

Harris, LA ;

Goff, JD ;

Carmichael, AY ;

Riffle, JS ;

Harburn, JJ ;

St Pierre, TG ;

Saunders, M .

CHEMISTRY OF MATERIALS, 2003, 15 (06) :1367-1377

[13] Preparation of thermo-sensitive magnetic hydrogel microspheres and application to enzyme immobilization [J].

Kondo, A ;

Fukuda, H .

JOURNAL OF FERMENTATION AND BIOENGINEERING, 1997, 84 (04) :337-341

[14]

Kubo T, 2000, INT J ONCOL, V17, P309

[15] Magnetic and hydrogel composite materials for hyperthermia applications [J].

Lao, LL ;

Ramanujan, RV .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2004, 15 (10) :1061-1064

[16] Physiological aspects in magnetic drug-targeting [J].

Lübbe, AS ;

Bergemann, C ;

Brock, J ;

McClure, DG .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1999, 194 (1-3) :149-155

[17] Improved method of recombinant AAV2 delivery for systemic targeted gene therapy [J].

Mah, C ;

Fraites, TJ ;

Zolotukhin, I ;

Song, SH ;

Flotte, TR ;

Dobson, J ;

Batich, C ;

Byrne, BJ .

MOLECULAR THERAPY, 2002, 6 (01) :106-112

[18] MAGNETOFERRITIN - INVITRO SYNTHESIS OF A NOVEL MAGNETIC PROTEIN [J].

MELDRUM, FC ;

HEYWOOD, BR ;

MANN, S .

SCIENCE, 1992, 257 (5069) :522-523

[19] PREPARATION AND APPLICATION OF MAGNETIC POLYMERS FOR TARGETING OF DRUGS [J].

MOSBACH, K ;

SCHRODER, U .

FEBS LETTERS, 1979, 102 (01) :112-116

[20] Superparamagnetic nanoparticles for biomedical applications:: Possibilities and limitations of a new drug delivery system [J].

Neuberger, T ;

Schöpf, B ;

Hofmann, H ;

Hofmann, M ;

von Rechenberg, B .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2005, 293 (01) :483-496

← 1 2 3 4 →