Reactive Oxygen Species in Cancer Biology and Anticancer Therapy

被引:106
作者
Yang, Y. [1 ,2 ]
Karakhanova, S. [1 ]
Werner, J. [1 ]
Bazhin, A. V. [1 ]
机构
[1] Heidelberg Univ, Dept Gen Surg, Heidelberg, Germany
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Ctr Canc, Wuhan 430074, Peoples R China
关键词
Antioxidants; cancer biology; cancer progression; cancer therapy; carcinogenesis; reactive oxygen species; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; PROTEIN-KINASE-C; SQUAMOUS-CELL CARCINOMA; OXIDATIVE DNA-DAMAGE; PROSTATE-CANCER; SUPEROXIDE-DISMUTASE; NADPH OXIDASE; LIPID-PEROXIDATION; PANCREATIC-CANCER;
D O I
10.2174/0929867311320999165
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Reactive oxygen species (ROS) are a group of highly reactive chemicals under tight control of intracellular antioxidants. The balance in oxidation-antioxidation is essential for maintaining normal cell functions, and any imbalance could lead to a wide range of diseases including cancer. The intracellular level of ROS is generally elevated in cancer cells, revealing a critical role of ROS in the process of carcinogenesis and cancer progression. Conversely, there is also evidence showing that ROS can act as cancer suppressors. This may be due to the varying antioxidant capacities of different cancers. These findings indicate a complex redox state in cancer cells. In this review we summarize the main features of ROS and their functions with respect to cancer initiation, hallmarks of cancer, and signaling in cancer cells. ROS-elevating and ROS-depleting anticancer strategies and their mechanisms are thoroughly discussed. We argue that the rationale for therapy choice depends on a complete understanding of cancer cell redox state, namely, the "redox signaling signature" of cancer.
引用
收藏
页码:3677 / 3692
页数:16
相关论文
共 193 条
  • [1] Novel action of paclitaxel against cancer cells: Bystander effect mediated by reactive oxygen species
    Alexandre, Jerome
    Hu, Yumin
    Lu, Weiqin
    Pelicano, Helene
    Huang, Peng
    [J]. CANCER RESEARCH, 2007, 67 (08) : 3512 - 3517
  • [2] Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group, 1994, N Engl J Med, V330, P1029, DOI 10.1056/NEJM199404143301501
  • [3] THE CAUSES AND PREVENTION OF CANCER
    AMES, BN
    GOLD, LS
    WILLETT, WC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (12) : 5258 - 5265
  • [4] [Anonymous], COCHRANE DATABASE SY
  • [5] Arain MA, 2010, PAK J PHARM SCI, V23, P125
  • [6] The role of glutathione in brain tumor drug resistance
    Backos, Donald S.
    Franklin, Christopher C.
    Reigan, Philip
    [J]. BIOCHEMICAL PHARMACOLOGY, 2012, 83 (08) : 1005 - 1012
  • [7] Bahlis NJ, 2002, CLIN CANCER RES, V8, P3658
  • [8] The role of glutathione in cancer
    Balendiran, GK
    Dabur, R
    Fraser, D
    [J]. CELL BIOCHEMISTRY AND FUNCTION, 2004, 22 (06) : 343 - 352
  • [9] Batarseh KI, 2012, CURR MED CHEM, V19, P3635
  • [10] The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    Bedard, Karen
    Krause, Karl-Heinz
    [J]. PHYSIOLOGICAL REVIEWS, 2007, 87 (01) : 245 - 313