Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9)

被引:22
作者
Westermeier, Francisco [1 ,2 ]
Bustamante, Mario [1 ,2 ]
Pavez, Mario [1 ,2 ]
Garcia, Lorena [1 ,2 ]
Chiong, Mario [1 ,2 ]
Paz Ocaranza, Maria [3 ,4 ]
Lavandero, Sergio [1 ,2 ,5 ,6 ]
机构
[1] Univ Chile, Adv Ctr Chron Dis ACCDiS, Fac Ciencias Quim & Farmaceut, Santiago 8380492, Chile
[2] Univ Chile, Fac Med, Santiago 8380492, Chile
[3] Pontificia Univ Catolica Chile, Adv Ctr Chron Dis ACCDiS, Fac Med, Santiago, Chile
[4] Pontificia Univ Catolica Chile, Div Enfermedades Cardiovasc, Fac Med, Santiago, Chile
[5] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX 75390 USA
[6] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA
关键词
Cardioprotection; Growth factor; Renin-angiotensin system; Cardiovascular diseases; Insulin-like growth factor-1; Angiotensin-(1-7); Angiotensin-(1-9); NITRIC-OXIDE SYNTHASE; G-PROTEIN; RECEPTOR MAS; ENDOTHELIAL DYSFUNCTION; HYBRID RECEPTORS; IGF-1; RECEPTOR; AT(2) RECEPTOR; HEART-FAILURE; UP-REGULATION; CONTRACTILE DYSFUNCTION;
D O I
10.1016/j.phrs.2015.06.018
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions in the heart (i.e., contractility, metabolism, hypertrophy, autophagy, senescence and cell death) and, conversely, its deficiency is associated with impaired cardiac function. Recently, we reported that insulin like growth factor-1 receptor is also located in plasma membrane invaginations with perinuclear localization, highlighting the role of nuclear Ca2+ signaling in the heart. In parallel, angiotensin-(1-7) and angiotensin (1-9) acting through Mas receptor and angiotensin type 2 receptor have emerged as a novel anti-hypertensive molecules promoting vasodilatation and preventing heart hypertrophy. In this review we discuss the scientific evidence available regarding insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) in cardioprotection and its potential application as novel therapeutic targets for treating cardiac diseases. (c) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:41 / 55
页数:15
相关论文
共 183 条
[71]  
KAMBAYASHI Y, 1993, J BIOL CHEM, V268, P24543
[72]   Angiotensin AT1/AT2 receptors: Regulation, signalling and function [J].
Kaschina, E ;
Unger, T .
BLOOD PRESSURE, 2003, 12 (02) :70-88
[73]   Efficacy and safety of m mecasermin rinfabate [J].
Kemp, Stephen F. ;
Fowlkes, John L. ;
Thrailkill, Kathryn M. .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2006, 6 (05) :533-538
[74]   OPINION Signalling bias in new drug discovery: detection, quantification and therapeutic impact [J].
Kenakin, Terry ;
Christopoulos, Arthur .
NATURE REVIEWS DRUG DISCOVERY, 2013, 12 (03) :205-216
[75]   Coupling of the insulin-like growth factor-I receptor tyrosine kinase to G12 in human intestinal smooth muscle -: Gβγ-Dependent mitogen-activated protein kinase activation and growth [J].
Keummerle, JF ;
Murthy, KS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (10) :7187-7194
[76]   Insulin-Like Growth Factor I Receptor Signaling Is Required for Exercise-Induced Cardiac Hypertrophy [J].
Kim, Jaetaek ;
Wende, Adam R. ;
Sena, Sandra ;
Theobald, Heather A. ;
Soto, Jamie ;
Sloan, Crystal ;
Wayment, Benjamin E. ;
Litwin, Sheldon E. ;
Holzenberger, Martin ;
LeRoith, Derek ;
Abel, E. Dale .
MOLECULAR ENDOCRINOLOGY, 2008, 22 (11) :2531-2543
[77]   Chronic treatment with insulin-like growth factor I enhances myocyte contraction by upregulation of Akt-SERCA2a signaling pathway [J].
Kim, Song-Jung ;
Abdellatif, Maha ;
Koul, Sharat ;
Crystal, George J. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 295 (01) :H130-H135
[78]   mTOR: a pharmacologic target for autophagy regulation [J].
Kim, Young Chul ;
Guan, Kun-Liang .
JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (01) :25-32
[79]   Molecular cloning and characterization of two novel genes on chromosome 8p21.3 [J].
Kinjo, T ;
Isomura, M ;
Iwamasa, T ;
Nakamura, Y .
JOURNAL OF HUMAN GENETICS, 2000, 45 (01) :12-17
[80]   Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes [J].
Kinugawa, S ;
Tsutsui, H ;
Ide, T ;
Nakamura, R ;
Arimura, K ;
Egashira, K ;
Takeshita, A .
CARDIOVASCULAR RESEARCH, 1999, 43 (01) :157-164