Cancer-Type-Specific Bacteria: Freeloaders or Partners?

被引:13
作者
Greathouse, K. Leigh [1 ]
Stone, Joshua K. [2 ]
Harris, Curtis C. [2 ]
机构
[1] Baylor Univ, Human Sci & Design, Robbins Coll Hlth & Human Sci, Waco, TX 76798 USA
[2] NCI, Lab Human Carcinogenesis, Ctr Canc Res, Bldg 37, Bethesda, MD 20892 USA
关键词
MICROBIOTA; P53;
D O I
10.1016/j.ccell.2020.06.017
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A paper published in Science probes over 1500 tumor samples from multiple cancer types for markers of a tumor microbiome and viable bacteria. Unique intertumoral and intracellular signatures associated with clinical biomarkers and metabolic pathways provide clues to the roles bacteria play in carcinogenesis.
引用
收藏
页码:158 / 160
页数:3
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共 10 条
  • [1] Distinct Microbial Signatures Associated With Different Breast Cancer Types
    Banerjee, Sagarika
    Tian, Tian
    Wei, Zhi
    Shih, Natalie
    Feldman, Michael D.
    Peck, Kristen N.
    DeMichele, Angela M.
    Alwine, James C.
    Robertson, Erle S.
    [J]. FRONTIERS IN MICROBIOLOGY, 2018, 9
  • [2] Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses
    Blagih, Julianne
    Zani, Fabio
    Chakravarty, Probir
    Hennequart, Marc
    Pilley, Steven
    Hobor, Sebastijan
    Hock, Andreas K.
    Walton, Josephine B.
    Morton, Jennifer P.
    Gronroos, Eva
    Mason, Susan
    Yang, Ming
    McNeish, Iain
    Swanton, Charles
    Blyth, Karen
    Vousden, Karen H.
    [J]. CELL REPORTS, 2020, 30 (02): : 481 - +
  • [3] Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
    Bullman, Susan
    Pedamallu, Chandra S.
    Sicinska, Ewa
    Claney, Thomas E.
    Zhang, Xiaoyang
    Cai, Diana
    Neuberg, Donna
    Huang, Katherine
    Guevara, Fatima
    Nelson, Timothy
    Chipashvili, Otari
    Hagan, Timothy
    Walker, Mark
    Ramachandran, Aruna
    Diosdado, Begona
    Serna, Garazi
    Mulet, Nuria
    Landolfi, Stefania
    Ramon y Cajal, Santiago
    Fasani, Roberta
    Aguirre, Andrew J.
    Ng, Kimmie
    Elez, Elena
    Ogino, Shuji
    Tabernero, Josep
    Fuchs, Charles S.
    Hahn, William C.
    Nuciforo, Paolo
    Meyerson, Matthew
    [J]. SCIENCE, 2017, 358 (6369) : 1443 - +
  • [4] The gut microbiota and colon cancer
    Garrett, Wendy S.
    [J]. SCIENCE, 2019, 364 (6446) : 1133 - 1135
  • [5] Interaction between the microbiome and TP53 in human lung cancer
    Greathouse, K. Leigh
    White, James R.
    Vargas, Ashely J.
    Bliskovsky, Valery V.
    Beck, Jessica A.
    von Muhlinen, Natalia
    Polley, Eric C.
    Bowman, Elise D.
    Khan, Mohammed A.
    Robles, Ana, I
    Cooks, Tomer
    Ryan, Brid M.
    Padgett, Noah
    Dzutsev, Amiran H.
    Trinchieri, Giorgio
    Pineda, Marbin A.
    Bilke, Sven
    Meltzer, Paul S.
    Hokenstad, Alexis N.
    Stickrod, Tricia M.
    Walther-Antonio, Marina R.
    Earl, Joshua P.
    Mell, Joshua C.
    Krol, Jaroslaw E.
    Balashov, Sergey, V
    Bhat, Archana S.
    Ehrlich, Garth D.
    Valm, Alex
    Deming, Clayton
    Conlan, Sean
    Oh, Julia
    Segre, Julie A.
    Harris, Curtis C.
    [J]. GENOME BIOLOGY, 2018, 19
  • [6] The human tumor microbiome is composed of tumor type-specific intracellular bacteria
    Nejman, Deborah
    Livyatan, Ilana
    Fuks, Garold
    Gavert, Nancy
    Zwang, Yaara
    Geller, Leore T.
    Rotter-Maskowitz, Aviva
    Weiser, Roi
    Mallel, Giuseppe
    Gigi, Elinor
    Meltser, Arnon
    Douglas, Gavin M.
    Kamer, Iris
    Gopalakrishnan, Vancheswaran
    Dadosh, Tali
    Levin-Zaidman, Smadar
    Avnet, Sofia
    Atlan, Tehila
    Cooper, Zachary A.
    Arora, Reetakshi
    Cogdill, Alexandria P.
    Khan, Md Abdul Wadud
    Ologun, Gabriel
    Bussi, Yuval
    Weinberger, Adina
    Lotan-Pompan, Maya
    Golani, Ofra
    Perry, Gili
    Rokah, Merav
    Bahar-Shany, Keren
    Rozeman, Elisa A.
    Blank, Christian U.
    Ronai, Anat
    Shaoul, Ron
    Amit, Amnon
    Dorfman, Tatiana
    Kremer, Ran
    Cohen, Zvi R.
    Harnof, Sagi
    Siegal, Tali
    Yehuda-Shnaidman, Einav
    Gal-Yam, Einav Nili
    Shapira, Hagit
    Baldini, Nicola
    Langille, Morgan G. I.
    Ben-Nun, Alon
    Kaufman, Bella
    Nissan, Aviram
    Golan, Talia
    Dadiani, Maya
    [J]. SCIENCE, 2020, 368 (6494) : 973 - +
  • [7] Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors
    Schwitalla, Sarah
    Ziegler, Paul K.
    Horst, David
    Becker, Valentin
    Kerle, Irina
    Begus-Nahrmann, Yvonne
    Lechel, Andre
    Rudolph, K. Lenhard
    Langer, Rupert
    Slotta-Huspenina, Julia
    Bader, Franz G.
    da Costa, Olivia Prazeres
    Neurath, Markus F.
    Meining, Alexander
    Kirchner, Thomas
    Greten, Florian R.
    [J]. CANCER CELL, 2013, 23 (01) : 93 - 106
  • [8] Invasive Potential of Gut Mucosa-derived Fusobacterium nucleatum Positively Correlates with IBD Status of the Host
    Strauss, Jaclyn
    Kaplan, Gilaad G.
    Beck, Paul L.
    Rioux, Kevin
    Panaccione, Remo
    DeVinney, Rebekah
    Lynch, Tarah
    Allen-Vercoe, Emma
    [J]. INFLAMMATORY BOWEL DISEASES, 2011, 17 (09) : 1971 - 1978
  • [9] The Microbiota of Breast Tissue and Its Association with Breast Cancer
    Urbaniak, Camilla
    Gloor, Gregory B.
    Brackstone, Muriel
    Scott, Leslie
    Tangney, Mark
    Reid, Gregor
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2016, 82 (16) : 5039 - 5048
  • [10] Sequence-Based Characterization of Intratumoral Bacteria-A Guide to Best Practice
    Walker, Sidney P.
    Tangney, Mark
    Claesson, Marcus J.
    [J]. FRONTIERS IN ONCOLOGY, 2020, 10