Uterine mesenchymal tumours: recent advances

被引：57
作者：
Momeni-Boroujeni, Amir [1 ]
Chiang, Sarah [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10044 USA
来源：
HISTOPATHOLOGY | 2020年 / 76卷 / 01期
关键词：
endometrial stromal sarcoma; epithelioid leiomyosarcoma; fibrosarcoma; myxoid leiomyosarcoma; undifferentiated uterine sarcoma; uterine tumour resembling ovarian sex cord tumour; ENDOMETRIAL STROMAL SARCOMA; SOLITARY FIBROUS TUMOR; SMALL-CELL CARCINOMA; SEX CORD TUMOR; HIGH-GRADE; FUSION ONCOGENES; GENE FUSIONS; CYCLIN D1; EXPRESSION; BCOR;
D O I：
10.1111/his.14008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Almost all uterine mesenchymal tumours have been historically classified as either smooth muscle or endometrial stromal neoplasms. Recent application of molecular techniques has identified numerous lesions with distinctive genetic abnormalities and clinicopathological characteristics. Newly discovered uterine sarcoma subtypes include high-grade endometrial stromal sarcomas withBCORgenetic abnormalities, fibrosarcoma-like uterine sarcomas withNTRKrearrangements andCOL1A-PDGFRBfusions, as well as undifferentiated uterine sarcomas withSMARCA4mutations. NovelPLAG1andPGRfusions have been identified in subsets of myxoid and epithelioid leiomyosarcomas. Some uterine tumours resembling ovarian sex-cord tumour harbourGREB1andESR1rearrangements. Histological and immunophenotypical features as well as underlying genetic abnormalities defining these lesions are discussed.
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收藏
页码：64 / 75
页数：12
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