Should phosphatidylethanol be currently analysed using whole blood, dried blood spots or both?

被引：4
作者：
Van Long Nguyen [1 ,2 ]
Fitzpatrick, Michael [1 ]
机构：
[1] Royal Prince Alfred Hosp, Dept Chem Pathol, NSW Hlth Pathol, Missenden Rd, Camperdown, NSW 2050, Australia
[2] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia
来源：
CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2019年 / 57卷 / 05期
关键词：
alcohol; dried blood spot; phosphatidylethanol; whole blood; ALCOHOL BIOMARKER PHOSPHATIDYLETHANOL; LIQUID-CHROMATOGRAPHY; CLINICAL-CHEMISTRY; HEMATOCRIT; PETH; CONSUMPTION; DRINKING; PREDICTION; SAMPLE;
D O I：
10.1515/cclm-2018-0667
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Phosphatidylethanol (PEth) are phospholipids produced through non-oxidative ethanol metabolism. They accumulate in red blood cells and have been traditionally analysed in whole blood as potential biomarkers for moderate to long-term alcohol consumption. More recently, their analysis in dried blood spots has been gaining favour, namely, due to the ease in sampling, transport and storage conditions required. This paper aims at providing a short comparative review between analysing PEth in whole blood and dried blood spots and the potential pitfalls that researchers may face when setting up PEth testing for clinical use.
引用
收藏
页码：617 / 622
页数：6
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