Age, the environment and our reproductive future: bonking baby boomers and the future of sex

被引:28
作者
Aitken, R. John [1 ]
机构
[1] Univ Newcastle, Prior Res Ctr Reprod Sci, Hunter Med Res Inst, Fac Sci & IT,Discipline Biol Sci, Newcastle, NSW 2308, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
LEUKOCYTE TELOMERE LENGTH; SPERM DNA-DAMAGE; MOBILE PHONE RADIATION; ADVANCED PATERNAL AGE; MALE GERM-LINE; OXIDATIVE STRESS; HUMAN SPERMATOZOA; BIRTH-DEFECTS; INFERTILE MEN; DIAGNOSTIC-CRITERIA;
D O I
10.1530/REP-13-0399
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
There has never been a greater need for scientists trained in reproductive science. Most developed countries are witnessing unprecedented rates of recourse to assisted conception sitting cheek-by-jowl with high rates of induced abortion. This article addresses these two incongruous faces of reproductive healthcare. Every year at least 44 million abortions are performed worldwide, many under unsafe and insanitary conditions that carry a significant risk to the lives of women deprived of safe, effective methods for controlling their fertility. Although birth control is a complex issue involving myriad social and political factors, the technical vacuum in this area is significant. Through no fault of the family planning authorities, there have been no radically new methods of fertility control since the oral contraceptive pill was introduced in 1960 and even this contribution to planned parenthood has its roots in the biochemistry of the 1920s and 1930s. Moreover, the pharmaceutical industry has, by and large, turned its back on fundamental research activities in this area. At present, our major investment in reproductive healthcare involves treating ever-increasing numbers of couples with assisted reproductive technologies (ART). However, these treatments are often delivered without critically considering the underlying causes of this condition or seriously contemplating the long-term consequences of the current enthusiasm for such therapy. Significantly, the clinical factors underpinning the commitment of couples to ART include advanced maternal age and a variety of lifestyle factors, such as smoking and obesity, which are known to compromise the developmental potential of the oocyte and DNA integrity in spermatozoa.
引用
收藏
页码:S1 / S11
页数:11
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