Update on current research into haploidentical hematopoietic stem cell transplantation

被引：21

作者：

Sun, Yu-Qian ^{[1
,2
]}

Chang, Ying-Jun ^{[1
,2
]}

Huang, Xiao-Jun ^{[1
,2
,3
]}

机构：

[1] Peking Univ, Inst Hematol, Peoples Hosp, Beijing, Peoples R China

[2] Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China

[3] Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China

来源：

EXPERT REVIEW OF HEMATOLOGY | 2018年 / 11卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Baltimore protocol; Beijing protocol; graft-versus-host disease; haploidentical stem cell transplantation; poor graft function; relapse; severe aplastic anemia; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; ACUTE MYELOID-LEUKEMIA; SEVERE APLASTIC-ANEMIA; REGULATORY T-CELLS; DOSE POSTTRANSPLANTATION CYCLOPHOSPHAMIDE; UNRELATED DONOR TRANSPLANTATION; COLONY-STIMULATING FACTOR; UMBILICAL-CORD BLOOD;

D O I：

10.1080/17474086.2018.1447379

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Haploidentical stem cell transplantation (Haplo-SCT) is currently a suitable alternative worldwide for patients with hematological diseases, who lack human leukocyte antigen (HLA)-matched siblings or unrelated donors.Areas covered: This review summarizes the advancements in Haplo-SCT in recent years, primarily focusing on the global trends of haploidentical allograft, the comparison of outcomes between Haplo-SCT and other transplantation modalities, strategies for improving clinical outcomes, including donor selection, hematopoietic reconstitution promotion, and graft-versus-host disease, and relapse prevention/management, as well as the expanded indications of Haplo-SCT, such as severe aplastic anemia, myeloma and lymphoma.Expert commentary: Haploidentical allografts, including granulocyte colony-stimulating factor-based protocol and a post-transplant cyclophosphamide-based protocol, have been the mainstream strategy for Haplo-SCT. However, there are many unanswered questions in this field.

引用

页码：273 / 284

页数：12

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