Ultrasmall porphyrin-silica core-shell dots for enhanced fluorescence imaging-guided cancer photodynamic therapy

被引：7

作者：

Hameed, Sadaf ^{[4
]}

Bhattarai, Pravin ^{[5
]}

Gong, Zhuoran ^{[1
]}

Liang, Xiaolong ^{[2
]}

Yue, Xiuli ^{[3
]}

Dai, Zhifei ^{[1
]}

机构：

[1] Peking Univ, Dept Biomed Engn, Coll Future Technol, Beijing 100871, Peoples R China

[2] Peking Univ Third Hosp, Dept Ultrasonog, Beijing 100191, Peoples R China

[3] Harbin Inst Technol, Sch Environm, Harbin 150001, Peoples R China

[4] Univ Cent Punjab, Fac Sci & Technol, Lahore 54000, Pakistan

[5] Univ Galway, CURAM SFI Res Ctr Med Devices, Biomed Sci, Galway, Ireland

来源：

NANOSCALE ADVANCES | 2022年 / 5卷 / 01期

基金：

中国国家自然科学基金; 国家自然科学基金国际合作与交流项目;

关键词：

TARGETED DELIVERY; NANOPARTICLES; DOXORUBICIN;

D O I：

10.1039/d2na00704e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Clinically used small-molecular photosensitizers (PSs) for photodynamic therapy (PDT) share similar disadvantages, such as the lack of selectivity towards cancer cells, short blood circulation time, life-threatening phototoxicity, and low physiological solubility. To overcome such limitations, the present study capitalizes on the synthesis of ultra-small hydrophilic porphyrin-based silica nanoparticles (core-shell porphyrin-silica dots; PSDs) to enhance the treatment outcomes of cancer via PDT. These ultra-small PSDs, with a hydrodynamic diameter less than 7 nm, have an excellent aqueous solubility in water (porphyrin; TPPS3-NH2) and enhanced tumor accumulation therefore exhibiting enhanced fluorescence imaging-guided PDT in breast cancer cells. Besides ultra-small size, such PSDs also displayed an excellent biocompatibility and negligible dark cytotoxicity in vitro. Moreover, PSDs were also found to be stable in other physiological solutions as a function of time. The fluorescence imaging of porphyrin revealed a prolonged residence time of PSDs in tumor regions, reduced accumulation in vital organs, and rapid renal clearance upon intravenous injection. The in vivo study further revealed reduced tumor growth in 4T1 tumor-bearing bulb mice after laser irradiation explaining the excellent photodynamic therapeutic efficacy of ultra-small PSDs. Thus, ultrasmall hydrophilic PSDs combined with excellent imaging-guided therapeutic abilities and renal clearance behavior represent a promising platform for cancer imaging and therapy.

引用

页码：277 / 289

页数：13