Parental infertility and sexual maturation in children

被引:7
作者
Zhu, Jin Liang [1 ]
Basso, Olga [2 ]
Obel, Carsten [1 ,3 ]
Bech, Bodil Hammer [1 ]
Nohr, Ellen Aagaard [1 ]
Shrestha, Anshu [4 ]
Olsen, Jorn [1 ,4 ]
机构
[1] Univ Aarhus, Inst Publ Hlth, Dept Epidemiol, Danish Epidemiol Sci Ctr, DK-8000 Aarhus C, Denmark
[2] NIEHS, Epidemiol Branch, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA
[3] Aarhus Univ Hosp, Dept Obstet & Gynaecol, Perinatal Epidemiol Res Unit, DK-8200 Aarhus N, Denmark
[4] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA
基金
英国医学研究理事会;
关键词
ASSISTED REPRODUCTIVE TECHNOLOGY; SECULAR TREND; SEMEN QUALITY; DENMARK; HEALTH; AGE; HYPOSPADIAS; MENARCHE; PUBERTY; BOYS;
D O I
10.1093/humrep/den366
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The reproductive health of children born of infertile couples may be affected by infertility treatment or factors associated with infertility. We examined sexual maturation in children of parents with infertility. We used data from a follow-up of 3382 girls and 2810 boys born between 1984 and 1987 in the Aalborg-Odense Birth Cohort. We had mothers' report of time to pregnancy (TTP) and infertility treatment (at the time, mostly hormonal) from the pregnancy questionnaire administered in 1984-1987, and the children's report of their own sexual maturation from the follow-up questionnaire administered in 2005, when they were between 18 and 21 years old. Many reported age only in year when they had the events related to sexual maturation, and for each event, we imputed the month based on the median month at each year of age among those reporting both years and months. In girls, the mean age at menarche was 13.3 years and, in boys, the mean age at appearance of acne, voice break, regular shaving and first nocturnal emission were 14.5, 14.5, 17.2 and 14.7 years, respectively. We saw no significant differences in age at these events among children born of either fertile (with TTP of 0-12 months and no treatment), untreated infertile (with TTP of more than 12 months and no treatment) or treated infertile couples (with a history of examination or treatment for infertility). Our data suggest no significant association between parental infertility or hormonal treatment and timing of sexual maturation in the offspring.
引用
收藏
页码:445 / 450
页数:6
相关论文
共 24 条
[1]   Size at birth predicts age at menarche [J].
Adair, LS .
PEDIATRICS, 2001, 107 (04) :E59
[2]  
Andersen AN, 2006, INT J ANDROL, V29, P12, DOI 10.1111/j.1365-2605.2005.00577.x
[3]   Increased frequency of reproductive health problems among fathers of boys with hypospadias [J].
Asklund, C. ;
Jorgensen, N. ;
Skakkebaek, N. E. ;
Jensen, T. K. .
HUMAN REPRODUCTION, 2007, 22 (10) :2639-2646
[4]   Medical outcome of 8-year-old singleton ICSI children (born ≥32 weeks' gestation) and a spontaneously conceived comparison group [J].
Belva, F. ;
Henriet, S. ;
Liebaers, I. ;
Van Steirteghem, A. ;
Celestin-Westreich, S. ;
Bonduelle, M. .
HUMAN REPRODUCTION, 2007, 22 (02) :506-515
[5]  
Boldsen J L, 1993, Ugeskr Laeger, V155, P482
[6]   Drugs in infertility and fetal safety [J].
Elizur, Shai E. ;
Tulandi, Togas .
FERTILITY AND STERILITY, 2008, 89 (06) :1595-1602
[7]   Public health implications of altered puberty timing [J].
Golub, Mari S. ;
Collman, Gwen W. ;
Foster, Paul M. D. ;
Kimmel, Carole A. ;
Meyts, Ewa Rajpert-De ;
Reiter, Edward O. ;
Sharpe, Richard M. ;
Skakkebaek, Niels E. ;
Toppari, Jorma .
PEDIATRICS, 2008, 121 :S218-S230
[8]   A halt in the secular trend towards earlier menarche in Denmark [J].
Helm, P ;
Gronlund, L .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1998, 77 (02) :198-200
[9]   DECREASE IN MENARCHEAL AGE FROM 1966 TO 1983 IN DENMARK [J].
HELM, P ;
HELM, S .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1984, 63 (07) :633-635
[10]   Genetics of puberty [J].
Herbison, Allan E. .
HORMONE RESEARCH, 2007, 68 :75-79