In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease

被引：89
作者：
Dronse, Julian [1 ,2 ]
Fliessbach, Klaus [3 ,4 ]
Bischof, Gerard N. [2 ,5 ]
von Reutern, Boris [1 ,2 ]
Faber, Jennifer [4 ,6 ]
Hammes, Jochen [5 ]
Kuhnert, Georg [5 ]
Neumaier, Bernd [7 ,8 ]
Onur, Oezguer A. [1 ,2 ]
Kukolja, Juraj [1 ,2 ]
van Eimeren, Thilo [1 ,2 ,4 ,5 ]
Jessen, Frank [4 ,9 ]
Fink, Gereon R. [1 ,2 ]
Klockgether, Thomas [4 ,6 ]
Drzezga, Alexander [4 ,5 ]
机构：
[1] Univ Hosp Cologne, Dept Neurol, Cologne, Germany
[2] Res Ctr J ulich, Inst Neurosci & Med INM 3, Cognit Neurosci, Julich, Germany
[3] Univ Hosp Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany
[4] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
[5] Univ Hosp Cologne, Dept Nucl Med, Multimodal Neuroimaging Grp, Cologne, Germany
[6] Univ Hosp Bonn, Dept Neurol, Bonn, Germany
[7] Res Ctr J ulich, Inst Neurosci & Med INM 5, Nuclear Chem, Julich, Germany
[8] Univ Hosp Cologne, Inst Radiochem & Expt Mol Imaging, Cologne, Germany
[9] Univ Hosp Cologne, Dept Psychiat, Cologne, Germany
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2017年 / 55卷 / 02期
关键词：
Alzheimer's disease; amyloid; F-18-AV-1451; F-18-FDG; molecular imaging; multimodal imaging; Pittsburgh compound B; positron-emission tomography; T-807; tau protein; NEUROPATHOLOGICALLY DEFINED SUBTYPES; POSTERIOR CORTICAL ATROPHY; NEUROFIBRILLARY TANGLES; HYPOMETABOLISM;
D O I：
10.3233/JAD-160316
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-beta. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-beta deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.
引用
收藏
页码：465 / 471
页数：7
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