Prognostic significance of insulin-like growth factor-I serum levels in acute decompensation of cirrhosis

被引：6

作者：

Colombo, Bruno da Silveira ^{[1
]}

Ronsoni, Marcelo Fernando ^{[1
]}

Soares e Silva, Pedro Eduardo ^{[1
]}

Fayad, Leonardo ^{[1
]}

Wildner, Leticia Muraro ^{[2
]}

Bazzo, Maria Luiza ^{[2
]}

Dantas-Correa, Esther Buzaglo ^{[1
]}

Narciso-Schiavon, Janaina Luz ^{[1
]}

Schiavon, Leonardo Lucca ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Div Gastroenterol, Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Clin Anal, Florianopolis, SC, Brazil

来源：

BIOMARKERS | 2017年 / 22卷 / 02期

关键词：

Liver cirrhosis; IGF-I; ascites; portal hypertension; FACTOR BINDING-PROTEINS; CHRONIC LIVER-FAILURE; ADULT PATIENTS; IGF-I; DISEASE; TRANSPLANTATION; MANAGEMENT; SURVIVAL; HORMONE; IGFBP-3;

D O I：

10.1080/1354750X.2016.1252949

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: IGF-I serum levels are suppressed in cirrhosis, but its prognostic significance is unknown. Objectives: To investigate the prognostic value of IGF-I in patients admitted for acute decompensation of cirrhosis. Materials and methods: Cohort study that included 103 patients. IGF-I was measured by enzymelinked immunosorbent assay (ELISA). Results: Ninety-day mortality was 26.2% and it was independently associated with MELD, age and IGFI. The Kaplan-Meier survival probability at 90 days was 94.3% in patients with IGF-I >= 13 mu g/mL and 63.2% for patients with IGF-I < 13 ng/mL (p = .001). Discussion and conclusion: IGF-I levels are independently associated with mortality in acute decompensation of cirrhosis.

引用

页码：127 / 132

页数：6

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