Opinion - Does nitric oxide modulate mitochondrial energy generation and apoptosis?

被引：642
作者：
Moncada, S
Erusalimsky, JD
机构：
[1] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England
[2] UCL, Dept Med, London WC1E 6BT, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 03期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm762
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The physiological role of nitric oxide (NO) in the maintenance of vascular tone, in synaptic transmission and in cellular defence is now firmly established. Recent evidence indicates that NO can also affect mitochondrial function. Here, we review findings indicating that NO - through its interaction with components of the electron-transport chain - might function not only as a physiological regulator of cell respiration, but also to augment the generation of reactive oxygen species by mitochondria, and thereby trigger mechanisms of cell survival or death.
引用
收藏
页码：214 / 220
页数：8
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