Microwave promoted rapid nitration of phenolic compounds with calcium nitrate

被引：48

作者：

Bose, AK ^{[1
]}

Ganguly, SN

Manhas, MS

Rao, S

Speck, J

Pekelny, U

Pombo-Villars, E

机构：

[1] Stevens Inst Technol, Dept Chem & Biol Chem, George Barasch Bioorgan Res Lab, Hoboken, NJ 07030 USA

[2] Novartis Pharmaceut Corp, E Hanover, NJ 07936 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 12期

关键词：

microwave-assisted nitration; Green chemistry approach; Mononitro phenol; calcium nitrate for nitration; N-15-labeled compounds;

D O I：

10.1016/j.tetlet.2006.01.094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly accelerated and safe nitration of phenolic compounds has been found to be feasible with a mixture of calcium nitrate and acetic acid as an efficient nitration agent under brief microwave irradiation. This method is compatible with the green chemistry approach because calcium salts-the inorganic byproducts-can be useful agrochemicals rather than waste chemicals. Commercially available N-15-labeled calcium nitrate is convenient for the preparation of N-15-labeled compounds for metabolic studies and mass spectrometry. This safe nitration method can be included in laboratory experiments for high school and college students. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1885 / 1888

页数：4

共 6 条

[1]

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[2]

BOSE AK, 2002, SYNTHESIS-STUTTGART, V1578, P1591

[3]

HUAROTTE MP, 2001, THESIS STEVENS I TEC

[4]

KRONETHAL DR, 1982, J ORG CHEM, V47, P383