Synthesis and Biological Activity of Novel Diphenyl N- Substituted Carbamimidoylphosphoramidate Derivatives

被引：10

作者：

Subramanyam, Ch ^{[1
]}

Ramana, K. Venkata ^{[1
]}

Rasheed, S. ^{[1
]}

Adam, S. ^{[2
]}

Raju, C. Naga ^{[1
]}

机构：

[1] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India

[2] Sree Vidyanikethan PG Coll, Dept Biochem, Tirupati, Andhra Pradesh, India

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2013年 / 188卷 / 09期

关键词：

Phosphoramidate derivatives; diphenyl phosphorochloridate; cyanamide; aromatic; heterocyclic amines; antiviral (TMV); antimicrobial activity; PHOSPHORAMIDATE MONOESTERS; 3'-AZIDO-3'-DEOXYTHYMIDINE;

D O I：

10.1080/10426507.2012.745075

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient synthesis of a series of novel diphenyl N-substituted carbamimidoyl phosphoramidate derivatives was accomplished in two steps. Diphenyl phosphorochloridate (1) was reacted with cyanamide (2) in the presence of 1,4-dimethylpiperazine as a base in THF at 50-55 degrees C to form an intermediate, diphenyl cyanophosphoramidate (3). Subsequently 3 was reacted with various aromatic/heterocyclic amines (4) in the presence of 1,4-dimethyl piperazine as a base at 55-60 degrees C to form the corresponding title compounds 5(a-k). The title compounds were tested for antiviral activity against Tobacco mosaic virus (TMV) in vitro, antibacterial and antifungal activities at two different concentrations of 50 and 100g/mL. The title compounds exhibited good antiviral and antimicrobial activities when compared to the standards.

引用

页码：1228 / 1235

页数：8

共 24 条

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[2]

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