Amygdalin Analogues Inhibit IFN-γ Signalling and Reduce the Inflammatory Response in Human Epidermal Keratinocytes

被引：25

作者：

Paoletti, Iole ^{[3
]}

De Gregorio, Vincenza ^{[3
]}

Baroni, Adone ^{[1
]}

Tufano, Maria Antonietta ^{[3
]}

Donnarumma, Giovanna ^{[3
]}

Jesus Perez, Juan ^{[2
]}

机构：

[1] Univ Naples 2, Dept Dermatol, I-80100 Naples, Italy

[2] ETSEIB, Dept Engn Quim UPC, Barcelona, Spain

[3] Univ Naples 2, Sect Microbiol & Clin Microbiol, Dept Expt Med, I-80100 Naples, Italy

来源：

INFLAMMATION | 2013年 / 36卷 / 06期

关键词：

PT; amygdalin analogues; NHEK cells; PSORIATIC SKIN; STAT FAMILY; PEPTIDE-T; EXPRESSION; CELLS; TRANSCRIPTION; IL-23; ACTIVATION; RECEPTOR; HEAT-SHOCK-PROTEIN-70;

D O I：

10.1007/s10753-013-9670-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120-coating protein, appears to be beneficial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes play a key role in conditioning the therapeutic effects of PT in psoriasis. The aim of this study was to explore the effects of PT and the peptidomimetic natural products, Dhurrin and Prunasin, on the expression of the IL-6, IL-8, IL-23, HSP70 and ICAM-1 on IFN-gamma and TNF-alpha-NHEK activated cells. Moreover, we analysed the interference of PT and its analogues through STAT-3 activation. Our results show that the analogues tested exhibit the beneficial biological effects of PT, suggesting the primary role of keratinocytes upon which PT and the peptidomimetics act directly, by reducing proinflammatory responses. Its reduction appears to be important for therapeutic approach in psoriasis pathogenesis.

引用

页码：1316 / 1326

页数：11

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