Could the menagerie of the gut microbiome really cure cancer? Hope or hype

被引：16

作者：

Abid, Muhammad Bilal ^{[1
,2
]}

机构：

[1] Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Med, Div Infect Dis, Milwaukee, WI 53226 USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2019年 / 7卷

关键词：

Immunotherapy; Adoptive cellular therapy; Chimeric antigen receptor (CAR) T-cells; Gut microbiome; Dysbiosis; CRISPR/cas9; ANTITUMOR IMMUNITY; IMMUNOTHERAPY; ANTI-CTLA-4; MELANOMA; EFFICACY; TUMOR; IMMUNOSURVEILLANCE; MICROENVIRONMENT; CHEMOTHERAPY; DIVERSITY;

D O I：

10.1186/s40425-019-0561-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The investigational scale of the gut microbiome is expanding rapidly. In 2018, the intersection of gut microbiota and immuno-oncology received much attention. While the impact of gut microbiota on the immune system was already established, the year received an exponential expansion of microbiome's role in the immunotherapy setting. The microbiome research pipeline is ripe for large-scale, prospective trials. Working knowledge of immune-based cancer treatments, heterogeneity in their responses and resistance mechanisms, relevant immunological and microbiological pathways and potential for gut microbiome in enhancing the responses, is critical.

引用

页数：7

共 58 条

[1] The revving up of CARs [J].

Abid, Muhammad Bilal .

GENE THERAPY, 2018, 25 (03) :162-162

[2] PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma [J].

Ansell, Stephen M. ;

Lesokhin, Alexander M. ;

Borrello, Ivan ;

Halwani, Ahmad ;

Scott, Emma C. ;

Gutierrez, Martin ;

Schuster, Stephen J. ;

Millenson, Michael M. ;

Cattry, Deepika ;

Freeman, Gordon J. ;

Rodig, Scott J. ;

Chapuy, Bjoern ;

Ligon, Azra H. ;

Zhu, Lili ;

Grosso, Joseph F. ;

Kim, Su Young ;

Timmerman, John M. ;

Shipp, Margaret A. ;

Armand, Philippe .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (04) :311-319

[3] Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Ando, Minoru ;

Kamada, Nobuhiko ;

Nagano, Yuji ;

Narushima, Seiko ;

Suda, Wataru ;

Imaoka, Akemi ;

Setoyama, Hiromi ;

Nagamori, Takashi ;

Ishikawa, Eiji ;

Shima, Tatsuichiro ;

Hara, Taeko ;

Kado, Shoichi ;

Jinnohara, Toshi ;

Ohno, Hiroshi ;

Kondo, Takashi ;

Toyooka, Kiminori ;

Watanabe, Eiichiro ;

Yokoyama, Shin-ichiro ;

Tokoro, Shunji ;

Mori, Hiroshi ;

Noguchi, Yurika ;

Morita, Hidetoshi ;

Ivanov, Ivaylo I. ;

Sugiyama, Tsuyoshi ;

Nunez, Gabriel ;

Camp, J. Gray ;

Hattori, Masahira ;

Umesaki, Yoshinori ;

Honda, Kenya .

CELL, 2015, 163 (02) :367-380

[4] Commensal bacteria Bifidobacterium stimulates an antitumor response via cross-reactivity [J].

Bessell, Catherine Ami .

CANCER IMMUNOLOGY RESEARCH, 2019, 7 (02)

[5] Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation [J].

Browne, Hilary P. ;

Forster, Samuel C. ;

Anonye, Blessing O. ;

Kumar, Nitin ;

Neville, B. Anne ;

Stares, Mark D. ;

Goulding, David ;

Lawley, Trevor D. .

NATURE, 2016, 533 (7604) :543-+

[6] Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab [J].

Chaput, N. ;

Lepage, P. ;

Coutzac, C. ;

Soularue, E. ;

Le Roux, K. ;

Monot, C. ;

Boselli, L. ;

Routier, E. ;

Cassard, L. ;

Collins, M. ;

Vaysse, T. ;

Marthey, L. ;

Eggermont, A. ;

Asvatourian, V. ;

Lanoy, E. ;

Mateus, C. ;

Robert, C. ;

Carbonnel, F. .

ANNALS OF ONCOLOGY, 2017, 28 (06) :1368-1379

[7] Elements of cancer immunity and the cancer-immune set point [J].

Chen, Daniel S. ;

Mellman, Ira .

NATURE, 2017, 541 (7637) :321-330

[8] Oncology Meets Immunology: The Cancer-Immunity Cycle [J].

Chen, Daniel S. ;

Mellman, Ira .

IMMUNITY, 2013, 39 (01) :1-10

[9] Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients [J].

Frankel, Arthur E. ;

Coughlin, Laura A. ;

Kim, Jiwoong ;

Froehlich, Thomas W. ;

Xie, Yang ;

Frenkel, Eugene P. ;

Koh, Andrew Y. .

NEOPLASIA, 2017, 19 (10) :848-855

[10] Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy [J].

Gao, Jianjun ;

Shi, Lewis Zhichang ;

Zhao, Hao ;

Chen, Jianfeng ;

Xiong, Liangwen ;

He, Qiuming ;

Chen, Tenghui ;

Roszik, Jason ;

Bernatchez, Chantale ;

Woodman, Scott E. ;

Chen, Pei-Ling ;

Hwu, Patrick ;

Allison, James P. ;

Futreal, Andrew ;

Wargo, Jennifer A. ;

Sharma, Padmanee .

CELL, 2016, 167 (02) :397-+

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