A three-component, Zn(OTf)2-mediated entry into trisubstituted 2-aminoimidazoles

被引：5

作者：

Lukin, Alexei ^{[1
]}

Bakholdina, Anna ^{[1
]}

Kryukova, Anna ^{[1
]}

Sapegin, Alexander ^{[2
]}

Krasavin, Mikhail ^{[2
]}

机构：

[1] MIREA Russian Technol Univ, Lomonosov Inst Fine Chem Technol, Moscow 119571, Russia

[2] St Petersburg State Univ, St Petersburg 199034, Russia

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 15卷

基金：

俄罗斯科学基金会;

关键词：

alkyne hydroamination; cyclocondensation; Lewis acid catalysis; multicomponent reactions; propargylurea;

D O I：

10.3762/bjoc.15.103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)(2)-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles. These findings are in contrast to the previously reported base-promoted unimolecular cyclization of propargylureas (leading to 2-imidazolones) and extend the range of Lewis acid-catalyzed azole syntheses based on N-carbonyl propargylamines.

引用

页码：1061 / 1064

页数：4

共 7 条

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