A divergent approach to the synthesis of simplexides and congeners via a late-stage olefin cross-metathesis reaction

被引：7
作者：
Li, Jiakun [1 ,2 ]
Li, Wei [2 ]
Yu, Biao [2 ]
机构：
[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 30期
关键词：
GLYCOSYL AMINO-ACIDS; OUTER CORE REGION; MARINE SPONGES; IMMUNOSUPPRESSIVE GLYCOLIPIDS; FATTY-ACIDS; EFFICIENT; METABOLITES; PHOSPHITE; STRATEGY; ANALOGS;
D O I：
10.1039/c3ob40552d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Simplexides constitute a unique group of imnnunosuppressive glycolipids that demonstrate antiproliferative activities against activated T-cell lymphocytes via a unique non-cytotoxic inhibition. To investigate the structure activity relationship of the varied long-chain secondary alcohols on simplexides, we developed an efficient and divergent route to the synthesis of simplexides and congeners, taking advantage of a late-stage olefin cross-metathesis reaction.
引用
收藏
页码：4971 / 4974
页数：4
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