The role of inflammation in age-related disease

被引：189

作者：

Howcroft, T. Kevin ^{[1
]}

Campisi, Judith ^{[2
,3
]}

Louis, Germaine Buck ^{[4
]}

Smith, Martyn T. ^{[5
]}

Wise, Bradley ^{[6
]}

Wyss-Coray, Tony ^{[7
]}

Augustine, Alison Deckhut ^{[8
]}

McElhaney, Janet E. ^{[9
]}

Kohanski, Ron ^{[10
]}

Sierra, Felipe ^{[10
]}

机构：

[1] NCI, Div Canc Biol, NIH, Bethesda, MD 20892 USA

[2] Buck Inst Res Aging, Novato, CA 94945 USA

[3] Lawrence Berkeley Natl Lab, Berkeley, CA 94702 USA

[4] NICHD, Off Director, NIH, Bethesda, MD 20892 USA

[5] Univ Calif Berkeley, Div Environm Hlth Sci, Berkeley, CA 94720 USA

[6] NIA, Div Neurosci, NIH, Bethesda, MD 20892 USA

[7] Stanford Univ, Dept Neurol & Neurol Sci, Sch Med, Stanford, CA 94305 USA

[8] NIAID, Div Allergy Immunol & Transplantat, NIH, Bethesda, MD 20892 USA

[9] Adv Med Res Inst Canada, Sudbury, ON P3E 5J1, Canada

[10] NIA, Div Aging Biol, NIH, Bethesda, MD 20892 USA

来源：

AGING-US | 2013年 / 5卷 / 01期

关键词：

D O I：

10.18632/aging.100531

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation in Age-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD. It is now recognized that a mild pro-inflammatory state is correlated with the major degenerative diseases of the elderly. The focus of the workshop was to better understand the origins and consequences of this low level chronic inflammation in order to design appropriate interventional studies aimed at improving healthspan. Four sessions explored the intrinsic, environmental exposures and immune pathways by which chronic inflammation are generated, sustained, and lead to age-associated diseases. At the conclusion of the workshop recommendations to accelerate progress toward understanding the mechanistic bases of chronic disease were identified.

引用

页码：84 / 93

页数：10