Solid-phase synthesis of apicidin A and a cyclic tetrapeptoid analogue

被引:13
作者
Berst, F
Ladlow, M
Holmes, AB
机构
[1] GSK Cambridge Technol Ctr, Cambridge CB2 1EW, England
[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
关键词
D O I
10.1039/b110068h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The solid-phase synthesis of the antiprotozoal cyclic tetrapeptide apicidin A is reported and its synthetic accessibility is contrasted with that of a structurally similar reduced cyclic tetrapeptoid analogue.
引用
收藏
页码:508 / 509
页数:2
相关论文
共 15 条
[1]   Design and synthesis of histone deacetylase inhibitors: the development of apicidin transition state analogs [J].
Colletti, SL ;
Myers, RW ;
Darkin-Rattray, SJ ;
Schmatz, DM ;
Fisher, MH ;
Wyvratt, MJ ;
Meinke, PT .
TETRAHEDRON LETTERS, 2000, 41 (41) :7837-7841
[2]   Tryptophan-replacement and indole-modifed apicidins: synthesis of potent and selective antiprotozoal agents [J].
Colletti, SL ;
Li, CS ;
Fisher, MH ;
Wyvratt, MJ ;
Meinke, PT .
TETRAHEDRON LETTERS, 2000, 41 (41) :7825-7829
[3]   Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase [J].
DarkinRattray, SJ ;
Gurnett, AM ;
Myers, RW ;
Dulski, PM ;
Crumley, TM ;
Allocco, JJ ;
Cannova, C ;
Meinke, PT ;
Colletti, SL ;
Bednarek, MA ;
Singh, SB ;
Goetz, MA ;
Dombrowski, AW ;
Polishook, JD ;
Schmatz, DM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :13143-13147
[4]  
El Haddadi M, 2000, J PEPT SCI, V6, P560, DOI 10.1002/1099-1387(200011)6:11<560::AID-PSC275>3.3.CO
[5]  
2-9
[6]  
GARNER P, 1992, ORG SYNTH, P70
[7]   Garner's aldehyde [J].
Liang, YF ;
Andersch, J ;
Bols, M .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (18) :2136-2157
[8]  
Liyuan M, 2001, TETRAHEDRON LETT, V42, P6603
[9]   Histone deacetylase: A target for antiproliferative and antiprotozoal agents [J].
Meinke, PT ;
Liberator, P .
CURRENT MEDICINAL CHEMISTRY, 2001, 8 (02) :211-235
[10]   Synthesis of apicidin-derived quinolone derivatives: Parasite-selective histone deacetylase inhibitors and antiproliferative agents [J].
Meinke, PT ;
Colletti, SL ;
Doss, G ;
Myers, RW ;
Gurnett, AM ;
Dulski, PM ;
Darkin-Rattray, SJ ;
Allocco, JJ ;
Galuska, S ;
Schmatz, DM ;
Wyvratt, MJ ;
Fisher, MH .
JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (25) :4919-4922